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Recent advances and safety issues of transgenic plant-derived vaccines
Transgenic plant-derived vaccines comprise a new type of bioreactor that combines plant genetic engineering technology with an organism's immunological response. This combination can be considered as a bioreactor that is produced by introducing foreign genes into plants that elicit special immu...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080054/ https://www.ncbi.nlm.nih.gov/pubmed/23447052 http://dx.doi.org/10.1007/s00253-012-4566-2 |
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author | Guan, Zheng-jun Guo, Bin Huo, Yan-lin Guan, Zheng-ping Dai, Jia-kun Wei, Ya-hui |
author_facet | Guan, Zheng-jun Guo, Bin Huo, Yan-lin Guan, Zheng-ping Dai, Jia-kun Wei, Ya-hui |
author_sort | Guan, Zheng-jun |
collection | PubMed |
description | Transgenic plant-derived vaccines comprise a new type of bioreactor that combines plant genetic engineering technology with an organism's immunological response. This combination can be considered as a bioreactor that is produced by introducing foreign genes into plants that elicit special immunogenicity when introduced into animals or human beings. In comparison with traditional vaccines, plant vaccines have some significant advantages, such as low cost, greater safety, and greater effectiveness. In a number of recent studies, antigen-specific proteins have been successfully expressed in various plant tissues and have even been tested in animals and human beings. Therefore, edible vaccines of transgenic plants have a bright future. This review begins with a discussion of the immune mechanism and expression systems for transgenic plant vaccines. Then, current advances in different transgenic plant vaccines will be analyzed, including vaccines against pathogenic viruses, bacteria, and eukaryotic parasites. In view of the low expression levels for antigens in plants, high-level expression strategies of foreign protein in transgenic plants are recommended. Finally, the existing safety problems in transgenic plant vaccines were put forward will be discussed along with a number of appropriate solutions that will hopefully lead to future clinical application of edible plant vaccines. |
format | Online Article Text |
id | pubmed-7080054 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-70800542020-03-23 Recent advances and safety issues of transgenic plant-derived vaccines Guan, Zheng-jun Guo, Bin Huo, Yan-lin Guan, Zheng-ping Dai, Jia-kun Wei, Ya-hui Appl Microbiol Biotechnol Mini-Review Transgenic plant-derived vaccines comprise a new type of bioreactor that combines plant genetic engineering technology with an organism's immunological response. This combination can be considered as a bioreactor that is produced by introducing foreign genes into plants that elicit special immunogenicity when introduced into animals or human beings. In comparison with traditional vaccines, plant vaccines have some significant advantages, such as low cost, greater safety, and greater effectiveness. In a number of recent studies, antigen-specific proteins have been successfully expressed in various plant tissues and have even been tested in animals and human beings. Therefore, edible vaccines of transgenic plants have a bright future. This review begins with a discussion of the immune mechanism and expression systems for transgenic plant vaccines. Then, current advances in different transgenic plant vaccines will be analyzed, including vaccines against pathogenic viruses, bacteria, and eukaryotic parasites. In view of the low expression levels for antigens in plants, high-level expression strategies of foreign protein in transgenic plants are recommended. Finally, the existing safety problems in transgenic plant vaccines were put forward will be discussed along with a number of appropriate solutions that will hopefully lead to future clinical application of edible plant vaccines. Springer-Verlag 2013-03-01 2013 /pmc/articles/PMC7080054/ /pubmed/23447052 http://dx.doi.org/10.1007/s00253-012-4566-2 Text en © Springer-Verlag Berlin Heidelberg 2013 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Mini-Review Guan, Zheng-jun Guo, Bin Huo, Yan-lin Guan, Zheng-ping Dai, Jia-kun Wei, Ya-hui Recent advances and safety issues of transgenic plant-derived vaccines |
title | Recent advances and safety issues of transgenic plant-derived vaccines |
title_full | Recent advances and safety issues of transgenic plant-derived vaccines |
title_fullStr | Recent advances and safety issues of transgenic plant-derived vaccines |
title_full_unstemmed | Recent advances and safety issues of transgenic plant-derived vaccines |
title_short | Recent advances and safety issues of transgenic plant-derived vaccines |
title_sort | recent advances and safety issues of transgenic plant-derived vaccines |
topic | Mini-Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080054/ https://www.ncbi.nlm.nih.gov/pubmed/23447052 http://dx.doi.org/10.1007/s00253-012-4566-2 |
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