Synthesis, antitubercular and anticancer activity of new Baylis–Hillman adduct-derived N-cinnamyl-substituted isatin derivatives

Baylis–Hillman adduct-derived N-cinnamyl-substituted isatin derivatives were synthesized and evaluated for their antitubercular activity on Mycobacterium tuberculosis H(37)Rv strain ATCC 27294 by agar dilution method. Anticancer activity for the same compounds was also screened on four different cel...

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Autores principales: Kumar, Sriramoju Bharath, Ravinder, Mettu, Kishore, Golla, Jayathirtha Rao, Vaidya, Yogeeswari, Perumal, Sriram, Darmarajan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080103/
https://www.ncbi.nlm.nih.gov/pubmed/32214765
http://dx.doi.org/10.1007/s00044-013-0787-x
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author Kumar, Sriramoju Bharath
Ravinder, Mettu
Kishore, Golla
Jayathirtha Rao, Vaidya
Yogeeswari, Perumal
Sriram, Darmarajan
author_facet Kumar, Sriramoju Bharath
Ravinder, Mettu
Kishore, Golla
Jayathirtha Rao, Vaidya
Yogeeswari, Perumal
Sriram, Darmarajan
author_sort Kumar, Sriramoju Bharath
collection PubMed
description Baylis–Hillman adduct-derived N-cinnamyl-substituted isatin derivatives were synthesized and evaluated for their antitubercular activity on Mycobacterium tuberculosis H(37)Rv strain ATCC 27294 by agar dilution method. Anticancer activity for the same compounds was also screened on four different cell lines: Chinese hamster ovary (CHO cells), Colo 205 (human colon cancer), Sup-T1 (human lymphoma) and C6 glioma (rat glioma) by MTT assay method. The compounds (3j–l) have shown significant activity against Mycobacterium strain and the compound 3l has shown specific cytotoxic activity.
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spelling pubmed-70801032020-03-23 Synthesis, antitubercular and anticancer activity of new Baylis–Hillman adduct-derived N-cinnamyl-substituted isatin derivatives Kumar, Sriramoju Bharath Ravinder, Mettu Kishore, Golla Jayathirtha Rao, Vaidya Yogeeswari, Perumal Sriram, Darmarajan Med Chem Res Original Research Baylis–Hillman adduct-derived N-cinnamyl-substituted isatin derivatives were synthesized and evaluated for their antitubercular activity on Mycobacterium tuberculosis H(37)Rv strain ATCC 27294 by agar dilution method. Anticancer activity for the same compounds was also screened on four different cell lines: Chinese hamster ovary (CHO cells), Colo 205 (human colon cancer), Sup-T1 (human lymphoma) and C6 glioma (rat glioma) by MTT assay method. The compounds (3j–l) have shown significant activity against Mycobacterium strain and the compound 3l has shown specific cytotoxic activity. Springer US 2013-09-26 2014 /pmc/articles/PMC7080103/ /pubmed/32214765 http://dx.doi.org/10.1007/s00044-013-0787-x Text en © Springer Science+Business Media New York 2013 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Research
Kumar, Sriramoju Bharath
Ravinder, Mettu
Kishore, Golla
Jayathirtha Rao, Vaidya
Yogeeswari, Perumal
Sriram, Darmarajan
Synthesis, antitubercular and anticancer activity of new Baylis–Hillman adduct-derived N-cinnamyl-substituted isatin derivatives
title Synthesis, antitubercular and anticancer activity of new Baylis–Hillman adduct-derived N-cinnamyl-substituted isatin derivatives
title_full Synthesis, antitubercular and anticancer activity of new Baylis–Hillman adduct-derived N-cinnamyl-substituted isatin derivatives
title_fullStr Synthesis, antitubercular and anticancer activity of new Baylis–Hillman adduct-derived N-cinnamyl-substituted isatin derivatives
title_full_unstemmed Synthesis, antitubercular and anticancer activity of new Baylis–Hillman adduct-derived N-cinnamyl-substituted isatin derivatives
title_short Synthesis, antitubercular and anticancer activity of new Baylis–Hillman adduct-derived N-cinnamyl-substituted isatin derivatives
title_sort synthesis, antitubercular and anticancer activity of new baylis–hillman adduct-derived n-cinnamyl-substituted isatin derivatives
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080103/
https://www.ncbi.nlm.nih.gov/pubmed/32214765
http://dx.doi.org/10.1007/s00044-013-0787-x
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