Synthesis of thiocarbohydrazide and carbohydrazide derivatives as possible biologically active agents

ABSTRACT: A series of new β-isatin aldehyde-N,N′-thiocarbohydrazone, bis-β-isatin thiocarbohydrazones, bis-β-isatin carbohydrazones was synthesized by condensation of 5-substituted isatin with thiocarbohydrazide or carbohydrazide. The chemical structures of the newly synthesized compounds were confi...

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Autores principales: Gangarapu, Kiran, Manda, Sarangapani, Jallapally, Anvesh, Thota, Sreekanth, Karki, Subhas S., Balzarini, Jan, De Clercq, Erik, Tokuda, Harukuni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080202/
https://www.ncbi.nlm.nih.gov/pubmed/32214764
http://dx.doi.org/10.1007/s00044-013-0684-3
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author Gangarapu, Kiran
Manda, Sarangapani
Jallapally, Anvesh
Thota, Sreekanth
Karki, Subhas S.
Balzarini, Jan
De Clercq, Erik
Tokuda, Harukuni
author_facet Gangarapu, Kiran
Manda, Sarangapani
Jallapally, Anvesh
Thota, Sreekanth
Karki, Subhas S.
Balzarini, Jan
De Clercq, Erik
Tokuda, Harukuni
author_sort Gangarapu, Kiran
collection PubMed
description ABSTRACT: A series of new β-isatin aldehyde-N,N′-thiocarbohydrazone, bis-β-isatin thiocarbohydrazones, bis-β-isatin carbohydrazones was synthesized by condensation of 5-substituted isatin with thiocarbohydrazide or carbohydrazide. The chemical structures of the newly synthesized compounds were confirmed by FT-IR, (1)H NMR, and mass spectral analysis. The synthesized compounds were evaluated for in vitro antiviral activity against various strains of DNA and RNA viruses, but exhibited moderate antiviral activity compared with the reference compounds. Among all the compounds 6c exhibited the highest chemoprevention activity in a two-stage mouse-skin carcinogenesis test. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-70802022020-03-23 Synthesis of thiocarbohydrazide and carbohydrazide derivatives as possible biologically active agents Gangarapu, Kiran Manda, Sarangapani Jallapally, Anvesh Thota, Sreekanth Karki, Subhas S. Balzarini, Jan De Clercq, Erik Tokuda, Harukuni Med Chem Res Original Research ABSTRACT: A series of new β-isatin aldehyde-N,N′-thiocarbohydrazone, bis-β-isatin thiocarbohydrazones, bis-β-isatin carbohydrazones was synthesized by condensation of 5-substituted isatin with thiocarbohydrazide or carbohydrazide. The chemical structures of the newly synthesized compounds were confirmed by FT-IR, (1)H NMR, and mass spectral analysis. The synthesized compounds were evaluated for in vitro antiviral activity against various strains of DNA and RNA viruses, but exhibited moderate antiviral activity compared with the reference compounds. Among all the compounds 6c exhibited the highest chemoprevention activity in a two-stage mouse-skin carcinogenesis test. GRAPHICAL ABSTRACT: [Image: see text] Springer US 2013-08-23 2014 /pmc/articles/PMC7080202/ /pubmed/32214764 http://dx.doi.org/10.1007/s00044-013-0684-3 Text en © Springer Science+Business Media New York 2013 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Research
Gangarapu, Kiran
Manda, Sarangapani
Jallapally, Anvesh
Thota, Sreekanth
Karki, Subhas S.
Balzarini, Jan
De Clercq, Erik
Tokuda, Harukuni
Synthesis of thiocarbohydrazide and carbohydrazide derivatives as possible biologically active agents
title Synthesis of thiocarbohydrazide and carbohydrazide derivatives as possible biologically active agents
title_full Synthesis of thiocarbohydrazide and carbohydrazide derivatives as possible biologically active agents
title_fullStr Synthesis of thiocarbohydrazide and carbohydrazide derivatives as possible biologically active agents
title_full_unstemmed Synthesis of thiocarbohydrazide and carbohydrazide derivatives as possible biologically active agents
title_short Synthesis of thiocarbohydrazide and carbohydrazide derivatives as possible biologically active agents
title_sort synthesis of thiocarbohydrazide and carbohydrazide derivatives as possible biologically active agents
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080202/
https://www.ncbi.nlm.nih.gov/pubmed/32214764
http://dx.doi.org/10.1007/s00044-013-0684-3
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