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Targeting glycosphingolipid metabolism as a potential therapeutic approach for treating disease in female MRL/lpr lupus mice

Glycosphingolipids (GSLs) hexosylceramides and lactosylceramides are elevated in lupus mice and human patients with nephritis. Whereas other renal diseases characterized by increased GSL levels are thought to be a result of upregulated GSL synthesis, our results suggest elevated hexosylceramides and...

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Detalles Bibliográficos
Autores principales:	Nowling, Tamara K., Rodgers, Jessalyn, Thiyagarajan, Thirumagal, Wolf, Bethany, Bruner, Evelyn, Sundararaj, Kamala, Molano, Ivan, Gilkeson, Gary
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080257/ https://www.ncbi.nlm.nih.gov/pubmed/32187230 http://dx.doi.org/10.1371/journal.pone.0230499

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