Cell fitness screens reveal a conflict between LINE-1 retrotransposition and DNA replication

LINE-1 retrotransposons are overexpressed in more than half of human cancers. We identified a colorectal cancer wherein a fast-growing tumor subclone downregulated LINE-1, prompting us to examine how LINE-1 expression affects cell growth. We find that non-transformed cells undergo a TP53-dependent g...

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Detalles Bibliográficos
Autores principales: Ardeljan, Daniel, Steranka, Jared P., Liu, Chunhong, Li, Zhi, Taylor, Martin S., Payer, Lindsay M., Gorbounov, Mikhail, Sarnecki, Jacob S., Deshpande, Vikram, Hruban, Ralph H., Boeke, Jef D., Fenyö, David, Wu, Pei-Hsun, Smogorzewska, Agata, Holland, Andrew J., Burns, Kathleen H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080318/
https://www.ncbi.nlm.nih.gov/pubmed/32042151
http://dx.doi.org/10.1038/s41594-020-0372-1

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