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Cytomorphological findings in diagnosis of Warthin tumor
BACKGROUND/AIM: To define the cytomorphologic findings leading to difficulties in diagnosis of Warthin tumors (WTs). MATERIALS AND METHODS: Forty-eight histopathologically diagnosed WT patients who had fine needle aspiration cytology preoperatively were reevaluated for defining the presence or absen...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Scientific and Technological Research Council of Turkey
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080357/ https://www.ncbi.nlm.nih.gov/pubmed/31769640 http://dx.doi.org/10.3906/sag-1901-215 |
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author | KÖYBAŞIOĞLU, Fatma Fulya ÖNAL, Binnur HAN, Ünsal ADABAĞ, Ayşegül ŞAHPAZ, Ahmet |
author_facet | KÖYBAŞIOĞLU, Fatma Fulya ÖNAL, Binnur HAN, Ünsal ADABAĞ, Ayşegül ŞAHPAZ, Ahmet |
author_sort | KÖYBAŞIOĞLU, Fatma Fulya |
collection | PubMed |
description | BACKGROUND/AIM: To define the cytomorphologic findings leading to difficulties in diagnosis of Warthin tumors (WTs). MATERIALS AND METHODS: Forty-eight histopathologically diagnosed WT patients who had fine needle aspiration cytology preoperatively were reevaluated for defining the presence or absence of lymphocytes, oncocytic cell layer, oncocytic cell papillae, granular debris background, mucoid background, macrophages, polymorphonuclear cells, mast cells, squamous-like cells, atypical vacuolated cytoplasmic cells, and giant cells. RESULTS: Forty-seven tumors were in the parotid gland and one in the submandibular gland. There were 37 (77%) male and 11 (23%) female patients. Cytopathologically in 36 patients the diagnosis was benign neoplasm (WT); in 6, other benign entities; and in 6, suspicious for malignancy. The main characteristic cytomorphologic features of WTs were as follows: 92% lymphoid cells, 83% oncocytic cell layers, and 67% granular debris background. These percentages were 67%, 17%, and 17% in the benign cytology group and 67%, 50%, and 17% in the suspicious for malignancy group, respectively. CONCLUSION: Absence or lack of main features of WTs with or without presence of squamous-like cells, vacuolated cytoplasmic cells, and inflammatory reaction may cause diagnostic dilemma. The presence of the mast cells accompanied by epithelial tissue was striking for WT diagnosis. |
format | Online Article Text |
id | pubmed-7080357 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Scientific and Technological Research Council of Turkey |
record_format | MEDLINE/PubMed |
spelling | pubmed-70803572020-03-23 Cytomorphological findings in diagnosis of Warthin tumor KÖYBAŞIOĞLU, Fatma Fulya ÖNAL, Binnur HAN, Ünsal ADABAĞ, Ayşegül ŞAHPAZ, Ahmet Turk J Med Sci Article BACKGROUND/AIM: To define the cytomorphologic findings leading to difficulties in diagnosis of Warthin tumors (WTs). MATERIALS AND METHODS: Forty-eight histopathologically diagnosed WT patients who had fine needle aspiration cytology preoperatively were reevaluated for defining the presence or absence of lymphocytes, oncocytic cell layer, oncocytic cell papillae, granular debris background, mucoid background, macrophages, polymorphonuclear cells, mast cells, squamous-like cells, atypical vacuolated cytoplasmic cells, and giant cells. RESULTS: Forty-seven tumors were in the parotid gland and one in the submandibular gland. There were 37 (77%) male and 11 (23%) female patients. Cytopathologically in 36 patients the diagnosis was benign neoplasm (WT); in 6, other benign entities; and in 6, suspicious for malignancy. The main characteristic cytomorphologic features of WTs were as follows: 92% lymphoid cells, 83% oncocytic cell layers, and 67% granular debris background. These percentages were 67%, 17%, and 17% in the benign cytology group and 67%, 50%, and 17% in the suspicious for malignancy group, respectively. CONCLUSION: Absence or lack of main features of WTs with or without presence of squamous-like cells, vacuolated cytoplasmic cells, and inflammatory reaction may cause diagnostic dilemma. The presence of the mast cells accompanied by epithelial tissue was striking for WT diagnosis. The Scientific and Technological Research Council of Turkey 2020-02-13 /pmc/articles/PMC7080357/ /pubmed/31769640 http://dx.doi.org/10.3906/sag-1901-215 Text en Copyright © 2019 The Author(s) This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Article KÖYBAŞIOĞLU, Fatma Fulya ÖNAL, Binnur HAN, Ünsal ADABAĞ, Ayşegül ŞAHPAZ, Ahmet Cytomorphological findings in diagnosis of Warthin tumor |
title | Cytomorphological findings in diagnosis of Warthin tumor |
title_full | Cytomorphological findings in diagnosis of Warthin tumor |
title_fullStr | Cytomorphological findings in diagnosis of Warthin tumor |
title_full_unstemmed | Cytomorphological findings in diagnosis of Warthin tumor |
title_short | Cytomorphological findings in diagnosis of Warthin tumor |
title_sort | cytomorphological findings in diagnosis of warthin tumor |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080357/ https://www.ncbi.nlm.nih.gov/pubmed/31769640 http://dx.doi.org/10.3906/sag-1901-215 |
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