Structure-based discovery of potent and selective melatonin receptor agonists

Melatonin receptors MT(1) and MT(2) are involved in synchronizing circadian rhythms and are important targets for treating sleep and mood disorders, type-2 diabetes and cancer. Here, we performed large scale structure-based virtual screening for new ligand chemotypes using recently solved high-resol...

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Detalles Bibliográficos
Autores principales: Patel, Nilkanth, Huang, Xi Ping, Grandner, Jessica M, Johansson, Linda C, Stauch, Benjamin, McCorvy, John D, Liu, Yongfeng, Roth, Bryan, Katritch, Vsevolod
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080406/
https://www.ncbi.nlm.nih.gov/pubmed/32118583
http://dx.doi.org/10.7554/eLife.53779

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080406/
https://www.ncbi.nlm.nih.gov/pubmed/32118583
http://dx.doi.org/10.7554/eLife.53779

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