Assessment of three essential tremor genetic loci in sporadic Parkinson's disease in Eastern China

OBJECTIVE: The aim of this study was to investigate potential genetic overlap between essential tremor and Parkinson's disease in a cohort of 825 subjects from an Eastern Chinese population. METHODS: A total of 441 Parkinson's disease patients and 384 healthy controls were recruited. The M...

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Detalles Bibliográficos
Autores principales: Gao, Ting, Wu, Jiong, Zheng, Ran, Fang, Yi, Jin, Chong‐Yao, Ruan, Yang, Cao, Jin, Tian, Jun, Pu, Jia‐Li, Zhang, Bao‐Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080431/
https://www.ncbi.nlm.nih.gov/pubmed/31755235
http://dx.doi.org/10.1111/cns.13272
Descripción
Sumario:OBJECTIVE: The aim of this study was to investigate potential genetic overlap between essential tremor and Parkinson's disease in a cohort of 825 subjects from an Eastern Chinese population. METHODS: A total of 441 Parkinson's disease patients and 384 healthy controls were recruited. The MassARRAY System was used to detect three essential tremor‐related single nucleotide polymorphisms. Odds ratio (OR) and 95% confidential interval (CI) were calculated to assess the relationship between polymorphisms and Parkinson's disease susceptibility. RESULTS: Our results demonstrated that the odds ratios of rs3794087 of SLC1A2, rs9652490 of LINGO1, and rs17590046 of PPARGC1A were 0.71 (95% CI = 0.55‐0.91), 0.99 (95% CI = 0.78‐1.26), and 0.88 (95% CI = 0.62‐1.25), respectively. CONCLUSION: An essential tremor SNP (rs3794087 of SLC1A2) is associated with a decreased risk of PD in the Eastern Han Chinese population, while rs9652490 (LINGO1) and rs17590046 (PPARGC1A) do not show an association.

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