Cargando…

Activation of adenosine A(2A) receptor by lipids from docosahexaenoic acid revealed by NMR

The lipid composition of the plasma membrane is a key parameter in controlling signal transduction through G protein–coupled receptors (GPCRs). Adenosine A(2A) receptor (A(2A)AR) is located in the lipid bilayers of cells, containing acyl chains derived from docosahexaenoic acid (DHA). For the NMR st...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mizumura, Takuya, Kondo, Keita, Kurita, Masatoshi, Kofuku, Yutaka, Natsume, Mei, Imai, Shunsuke, Shiraishi, Yutaro, Ueda, Takumi, Shimada, Ichio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080496/ https://www.ncbi.nlm.nih.gov/pubmed/32206717 http://dx.doi.org/10.1126/sciadv.aay8544

Ejemplares similares

Phosphorylation-induced conformation of β(2)-adrenoceptor related to arrestin recruitment revealed by NMR
por: Shiraishi, Yutaro, et al.
Publicado: (2018)

Function-Related Dynamics in Multi-Spanning Helical Membrane Proteins Revealed by Solution NMR
por: Takeuchi, Koh, et al.
Publicado: (2021)

Elucidation of the CCR1- and CCR5-binding modes of MIP-1α by application of an NMR spectra reconstruction method to the transferred cross-saturation experiments
por: Yoshiura, Chie, et al.
Publicado: (2015)

Development of a method for reconstruction of crowded NMR spectra from undersampled time-domain data
por: Ueda, Takumi, et al.
Publicado: (2015)

Identification of a Conformational Equilibrium That Determines the Efficacy and Functional Selectivity of the μ-Opioid Receptor
por: Okude, Junya, et al.
Publicado: (2015)

Biphasic activation of β-arrestin 1 upon interaction with a GPCR revealed by methyl-TROSY NMR
por: Shiraishi, Yutaro, et al.
Publicado: (2021)

Efficacy of the β(2)-adrenergic receptor is determined by conformational equilibrium in the transmembrane region
por: Kofuku, Yutaka, et al.
Publicado: (2012)

Activation mechanism of the μ-opioid receptor by an allosteric modulator
por: Kaneko, Shun, et al.
Publicado: (2022)

Dynamic domain arrangement of CheA-CheY complex regulates bacterial thermotaxis, as revealed by NMR
por: Minato, Yuichi, et al.
Publicado: (2017)

Conformational equilibrium shift underlies altered K(+) channel gating as revealed by NMR
por: Iwahashi, Yuta, et al.
Publicado: (2020)

Utilization of paramagnetic relaxation enhancements for structural analysis of actin-binding proteins in complex with actin
por: Huang, Shuxian, et al.
Publicado: (2016)

Dynamically regulated two-site interaction of viral RNA to capture host translation initiation factor
por: Imai, Shunsuke, et al.
Publicado: (2023)

Functional roles of Mg(2+) binding sites in ion-dependent gating of a Mg(2+) channel, MgtE, revealed by solution NMR
por: Maruyama, Tatsuro, et al.
Publicado: (2018)

Segmental isotopic labeling of a 140 kDa dimeric multi-domain protein CheA from Escherichia coli by expressed protein ligation and protein trans-splicing
por: Minato, Yuichi, et al.
Publicado: (2012)

Targeting the cryptic sites: NMR-based strategy to improve protein druggability by controlling the conformational equilibrium
por: Mizukoshi, Yumiko, et al.
Publicado: (2020)

Conformational landscape alternations promote oncogenic activities of Ras-related C3 botulinum toxin substrate 1 as revealed by NMR
por: Toyama, Yuki, et al.
Publicado: (2019)

Evaluation of Drug Responses to Human β(2)AR Using Native Mass Spectrometry
por: Tajiri, Michiko, et al.
Publicado: (2023)

Real-time monitoring of the reaction of KRAS G12C mutant specific covalent inhibitor by in vitro and in-cell NMR spectroscopy
por: Zhao, Qingci, et al.
Publicado: (2023)

Dynamic regulation of GDP binding to G proteins revealed by magnetic field-dependent NMR relaxation analyses
por: Toyama, Yuki, et al.
Publicado: (2017)

Dynamic equilibrium on DNA defines transcriptional regulation of a multidrug binding transcriptional repressor, LmrR
por: Takeuchi, Koh, et al.
Publicado: (2017)

Effects of dietary Docosahexaenoic, training and acute exercise on lipid mediators
por: Capó, X., et al.
Publicado: (2016)

Remodeling of lipid bodies by docosahexaenoic acid in activated microglial cells
por: Tremblay, Marie-Eve, et al.
Publicado: (2016)

Age Stratification and Impact of Eicosapentaenoic Acid and Docosahexaenoic Acid to Arachidonic Acid Ratios in Ischemic Stroke Patients
por: Ueno, Yuji, et al.
Publicado: (2018)

Structural mechanism underlying G protein family-specific regulation of G protein-gated inwardly rectifying potassium channel
por: Kano, Hanaho, et al.
Publicado: (2019)

Docosahexaenoic Acid-Loaded Nanostructured Lipid Carriers for the Treatment of Peri-Implantitis in Rats
por: Li, Zhen, et al.
Publicado: (2023)

Potential Clinical Applications of Pro-Resolving Lipids Mediators from Docosahexaenoic Acid
por: Beyer, María Paz, et al.
Publicado: (2023)

Dynamic multidrug recognition by multidrug transcriptional repressor LmrR
por: Takeuchi, Koh, et al.
Publicado: (2014)

Computational and NMR studies of RNA duplexes with an internal pseudouridine-adenosine base pair
por: Deb, Indrajit, et al.
Publicado: (2019)

Mechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization
por: Matsumura, Kazuki, et al.
Publicado: (2021)

Characterization of the multimeric structure of poly(A)-binding protein on a poly(A) tail
por: Sawazaki, Ryoichi, et al.
Publicado: (2018)

Paip2A inhibits translation by competitively binding to the RNA recognition motifs of PABPC1 and promoting its dissociation from the poly(A) tail
por: Sagae, Takeru, et al.
Publicado: (2022)

Chemopreventive and renal protective effects for docosahexaenoic acid (DHA): implications of CRP and lipid peroxides
por: El-Mesery, ME, et al.
Publicado: (2009)

Effects of Low Concentrations of Docosahexaenoic Acid on the Structure and Phase Behavior of Model Lipid Membranes
por: Lor, Chai, et al.
Publicado: (2015)

Effects of Docosahexaenoic Acid on Neurotransmission
por: Tanaka, Kazuhiro, et al.
Publicado: (2012)

Docosahexaenoic acid and the preterm infant
por: Smith, Stephanie L., et al.
Publicado: (2017)

Co-delivery of paclitaxel (PTX) and docosahexaenoic acid (DHA) by targeting lipid nanoemulsions for cancer therapy
por: Li, Bo, et al.
Publicado: (2021)

Lipid Structure Influences the Digestion and Oxidation Behavior of Docosahexaenoic and Eicosapentaenoic Acids in the Simulated Digestion System
por: Beltrame, Gabriele, et al.
Publicado: (2023)

Lipid Peroxidation via Regulating the Metabolism of Docosahexaenoic Acid and Arachidonic Acid in Autistic Behavioral Symptoms
por: Yui, Kunio, et al.
Publicado: (2023)

Arachidonic Acid and Docosahexaenoic Acid Metabolites in the Airways of Adults With Cystic Fibrosis: Effect of Docosahexaenoic Acid Supplementation
por: Teopompi, Elisabetta, et al.
Publicado: (2019)

Genome Sequence of Schizochytrium sp. CCTCC M209059, an Effective Producer of Docosahexaenoic Acid-Rich Lipids
por: Ji, Xiao-Jun, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_6tg3317tqi4jgi71osbhe8315j