BRCA1 Deficiency: BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis (Adv. Sci. 6/2020)

Mitophagy is a selective autophagic process for clearing damaged mitochondria and maintaining a healthy mitochondrial network. In article number https://doi.org/10.1002/advs.201903616, Qiang Chen, Chu‐Xia Deng, and co‐workers demonstrate breast cancer susceptibility gene 1 (BRCA1) facilitates mitoph...

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Detalles Bibliográficos
Autores principales: Chen, Qiang, Lei, Josh Haipeng, Bao, Jiaolin, Wang, Haitao, Hao, Wenhui, Li, Licen, Peng, Cheng, Masuda, Takaaki, Miao, Kai, Xu, Jun, Xu, Xiaoling, Deng, Chu‐Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Frontispiece
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080521/
http://dx.doi.org/10.1002/advs.202070033
Descripción
Sumario:Mitophagy is a selective autophagic process for clearing damaged mitochondria and maintaining a healthy mitochondrial network. In article number https://doi.org/10.1002/advs.201903616, Qiang Chen, Chu‐Xia Deng, and co‐workers demonstrate breast cancer susceptibility gene 1 (BRCA1) facilitates mitophagy to eliminate damaged mitochondria and reactive oxygen species through regulating mitochondrial dynamics, thereby blocking inflammasome activation to prevent mammary tumor metastasis. [Image: see text]

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