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BRCA1 Deficiency: BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis (Adv. Sci. 6/2020)
Mitophagy is a selective autophagic process for clearing damaged mitochondria and maintaining a healthy mitochondrial network. In article number https://doi.org/10.1002/advs.201903616, Qiang Chen, Chu‐Xia Deng, and co‐workers demonstrate breast cancer susceptibility gene 1 (BRCA1) facilitates mitoph...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080521/ http://dx.doi.org/10.1002/advs.202070033 |
| _version_ | 1783508024649842688 |
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| author | Chen, Qiang Lei, Josh Haipeng Bao, Jiaolin Wang, Haitao Hao, Wenhui Li, Licen Peng, Cheng Masuda, Takaaki Miao, Kai Xu, Jun Xu, Xiaoling Deng, Chu‐Xia |
| author_facet | Chen, Qiang Lei, Josh Haipeng Bao, Jiaolin Wang, Haitao Hao, Wenhui Li, Licen Peng, Cheng Masuda, Takaaki Miao, Kai Xu, Jun Xu, Xiaoling Deng, Chu‐Xia |
| author_sort | Chen, Qiang |
| collection | PubMed |
| description | Mitophagy is a selective autophagic process for clearing damaged mitochondria and maintaining a healthy mitochondrial network. In article number https://doi.org/10.1002/advs.201903616, Qiang Chen, Chu‐Xia Deng, and co‐workers demonstrate breast cancer susceptibility gene 1 (BRCA1) facilitates mitophagy to eliminate damaged mitochondria and reactive oxygen species through regulating mitochondrial dynamics, thereby blocking inflammasome activation to prevent mammary tumor metastasis. [Image: see text] |
| format | Online Article Text |
| id | pubmed-7080521 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-70805212020-03-19 BRCA1 Deficiency: BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis (Adv. Sci. 6/2020) Chen, Qiang Lei, Josh Haipeng Bao, Jiaolin Wang, Haitao Hao, Wenhui Li, Licen Peng, Cheng Masuda, Takaaki Miao, Kai Xu, Jun Xu, Xiaoling Deng, Chu‐Xia Adv Sci (Weinh) Frontispiece Mitophagy is a selective autophagic process for clearing damaged mitochondria and maintaining a healthy mitochondrial network. In article number https://doi.org/10.1002/advs.201903616, Qiang Chen, Chu‐Xia Deng, and co‐workers demonstrate breast cancer susceptibility gene 1 (BRCA1) facilitates mitophagy to eliminate damaged mitochondria and reactive oxygen species through regulating mitochondrial dynamics, thereby blocking inflammasome activation to prevent mammary tumor metastasis. [Image: see text] John Wiley and Sons Inc. 2020-03-18 /pmc/articles/PMC7080521/ http://dx.doi.org/10.1002/advs.202070033 Text en © 2020 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| spellingShingle | Frontispiece Chen, Qiang Lei, Josh Haipeng Bao, Jiaolin Wang, Haitao Hao, Wenhui Li, Licen Peng, Cheng Masuda, Takaaki Miao, Kai Xu, Jun Xu, Xiaoling Deng, Chu‐Xia BRCA1 Deficiency: BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis (Adv. Sci. 6/2020) |
| title | BRCA1 Deficiency: BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis (Adv. Sci. 6/2020) |
| title_full | BRCA1 Deficiency: BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis (Adv. Sci. 6/2020) |
| title_fullStr | BRCA1 Deficiency: BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis (Adv. Sci. 6/2020) |
| title_full_unstemmed | BRCA1 Deficiency: BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis (Adv. Sci. 6/2020) |
| title_short | BRCA1 Deficiency: BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis (Adv. Sci. 6/2020) |
| title_sort | brca1 deficiency: brca1 deficiency impairs mitophagy and promotes inflammasome activation and mammary tumor metastasis (adv. sci. 6/2020) |
| topic | Frontispiece |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080521/ http://dx.doi.org/10.1002/advs.202070033 |
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