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Defective Mitochondrial Fatty Acid Oxidation and Lipotoxicity in Kidney Diseases

The kidney is a highly metabolic organ and uses high levels of ATP to maintain electrolyte and acid-base homeostasis and reabsorb nutrients. Energy depletion is a critical factor in development and progression of various kidney diseases including acute kidney injury (AKI), chronic kidney disease (CK...

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Autores principales: Jang, Hee-Seong, Noh, Mi Ra, Kim, Jinu, Padanilam, Babu J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080698/
https://www.ncbi.nlm.nih.gov/pubmed/32226789
http://dx.doi.org/10.3389/fmed.2020.00065
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author Jang, Hee-Seong
Noh, Mi Ra
Kim, Jinu
Padanilam, Babu J.
author_facet Jang, Hee-Seong
Noh, Mi Ra
Kim, Jinu
Padanilam, Babu J.
author_sort Jang, Hee-Seong
collection PubMed
description The kidney is a highly metabolic organ and uses high levels of ATP to maintain electrolyte and acid-base homeostasis and reabsorb nutrients. Energy depletion is a critical factor in development and progression of various kidney diseases including acute kidney injury (AKI), chronic kidney disease (CKD), and diabetic and glomerular nephropathy. Mitochondrial fatty acid β-oxidation (FAO) serves as the preferred source of ATP in the kidney and its dysfunction results in ATP depletion and lipotoxicity to elicit tubular injury and inflammation and subsequent fibrosis progression. This review explores the current state of knowledge on the role of mitochondrial FAO dysfunction in the pathophysiology of kidney diseases including AKI and CKD and prospective views on developing therapeutic interventions based on mitochondrial energy metabolism.
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spelling pubmed-70806982020-03-27 Defective Mitochondrial Fatty Acid Oxidation and Lipotoxicity in Kidney Diseases Jang, Hee-Seong Noh, Mi Ra Kim, Jinu Padanilam, Babu J. Front Med (Lausanne) Medicine The kidney is a highly metabolic organ and uses high levels of ATP to maintain electrolyte and acid-base homeostasis and reabsorb nutrients. Energy depletion is a critical factor in development and progression of various kidney diseases including acute kidney injury (AKI), chronic kidney disease (CKD), and diabetic and glomerular nephropathy. Mitochondrial fatty acid β-oxidation (FAO) serves as the preferred source of ATP in the kidney and its dysfunction results in ATP depletion and lipotoxicity to elicit tubular injury and inflammation and subsequent fibrosis progression. This review explores the current state of knowledge on the role of mitochondrial FAO dysfunction in the pathophysiology of kidney diseases including AKI and CKD and prospective views on developing therapeutic interventions based on mitochondrial energy metabolism. Frontiers Media S.A. 2020-03-12 /pmc/articles/PMC7080698/ /pubmed/32226789 http://dx.doi.org/10.3389/fmed.2020.00065 Text en Copyright © 2020 Jang, Noh, Kim and Padanilam. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Jang, Hee-Seong
Noh, Mi Ra
Kim, Jinu
Padanilam, Babu J.
Defective Mitochondrial Fatty Acid Oxidation and Lipotoxicity in Kidney Diseases
title Defective Mitochondrial Fatty Acid Oxidation and Lipotoxicity in Kidney Diseases
title_full Defective Mitochondrial Fatty Acid Oxidation and Lipotoxicity in Kidney Diseases
title_fullStr Defective Mitochondrial Fatty Acid Oxidation and Lipotoxicity in Kidney Diseases
title_full_unstemmed Defective Mitochondrial Fatty Acid Oxidation and Lipotoxicity in Kidney Diseases
title_short Defective Mitochondrial Fatty Acid Oxidation and Lipotoxicity in Kidney Diseases
title_sort defective mitochondrial fatty acid oxidation and lipotoxicity in kidney diseases
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080698/
https://www.ncbi.nlm.nih.gov/pubmed/32226789
http://dx.doi.org/10.3389/fmed.2020.00065
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