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Defective Mitochondrial Fatty Acid Oxidation and Lipotoxicity in Kidney Diseases
The kidney is a highly metabolic organ and uses high levels of ATP to maintain electrolyte and acid-base homeostasis and reabsorb nutrients. Energy depletion is a critical factor in development and progression of various kidney diseases including acute kidney injury (AKI), chronic kidney disease (CK...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080698/ https://www.ncbi.nlm.nih.gov/pubmed/32226789 http://dx.doi.org/10.3389/fmed.2020.00065 |
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author | Jang, Hee-Seong Noh, Mi Ra Kim, Jinu Padanilam, Babu J. |
author_facet | Jang, Hee-Seong Noh, Mi Ra Kim, Jinu Padanilam, Babu J. |
author_sort | Jang, Hee-Seong |
collection | PubMed |
description | The kidney is a highly metabolic organ and uses high levels of ATP to maintain electrolyte and acid-base homeostasis and reabsorb nutrients. Energy depletion is a critical factor in development and progression of various kidney diseases including acute kidney injury (AKI), chronic kidney disease (CKD), and diabetic and glomerular nephropathy. Mitochondrial fatty acid β-oxidation (FAO) serves as the preferred source of ATP in the kidney and its dysfunction results in ATP depletion and lipotoxicity to elicit tubular injury and inflammation and subsequent fibrosis progression. This review explores the current state of knowledge on the role of mitochondrial FAO dysfunction in the pathophysiology of kidney diseases including AKI and CKD and prospective views on developing therapeutic interventions based on mitochondrial energy metabolism. |
format | Online Article Text |
id | pubmed-7080698 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70806982020-03-27 Defective Mitochondrial Fatty Acid Oxidation and Lipotoxicity in Kidney Diseases Jang, Hee-Seong Noh, Mi Ra Kim, Jinu Padanilam, Babu J. Front Med (Lausanne) Medicine The kidney is a highly metabolic organ and uses high levels of ATP to maintain electrolyte and acid-base homeostasis and reabsorb nutrients. Energy depletion is a critical factor in development and progression of various kidney diseases including acute kidney injury (AKI), chronic kidney disease (CKD), and diabetic and glomerular nephropathy. Mitochondrial fatty acid β-oxidation (FAO) serves as the preferred source of ATP in the kidney and its dysfunction results in ATP depletion and lipotoxicity to elicit tubular injury and inflammation and subsequent fibrosis progression. This review explores the current state of knowledge on the role of mitochondrial FAO dysfunction in the pathophysiology of kidney diseases including AKI and CKD and prospective views on developing therapeutic interventions based on mitochondrial energy metabolism. Frontiers Media S.A. 2020-03-12 /pmc/articles/PMC7080698/ /pubmed/32226789 http://dx.doi.org/10.3389/fmed.2020.00065 Text en Copyright © 2020 Jang, Noh, Kim and Padanilam. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Jang, Hee-Seong Noh, Mi Ra Kim, Jinu Padanilam, Babu J. Defective Mitochondrial Fatty Acid Oxidation and Lipotoxicity in Kidney Diseases |
title | Defective Mitochondrial Fatty Acid Oxidation and Lipotoxicity in Kidney Diseases |
title_full | Defective Mitochondrial Fatty Acid Oxidation and Lipotoxicity in Kidney Diseases |
title_fullStr | Defective Mitochondrial Fatty Acid Oxidation and Lipotoxicity in Kidney Diseases |
title_full_unstemmed | Defective Mitochondrial Fatty Acid Oxidation and Lipotoxicity in Kidney Diseases |
title_short | Defective Mitochondrial Fatty Acid Oxidation and Lipotoxicity in Kidney Diseases |
title_sort | defective mitochondrial fatty acid oxidation and lipotoxicity in kidney diseases |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080698/ https://www.ncbi.nlm.nih.gov/pubmed/32226789 http://dx.doi.org/10.3389/fmed.2020.00065 |
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