The COX-2/PGE(2) pathway suppresses apical elimination of RasV12-transformed cells from epithelia

At the initial stage of carcinogenesis, when RasV12-transformed cells are surrounded by normal epithelial cells, RasV12 cells are apically extruded from epithelia through cell competition with the surrounding normal cells. In this study, we demonstrate that expression of cyclooxygenase (COX)−2 is up...

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Detalles Bibliográficos
Autores principales: Sato, Nanami, Yako, Yuta, Maruyama, Takeshi, Ishikawa, Susumu, Kuromiya, Keisuke, Tokuoka, Suzumi M., Kita, Yoshihiro, Fujita, Yasuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080752/
https://www.ncbi.nlm.nih.gov/pubmed/32188886
http://dx.doi.org/10.1038/s42003-020-0847-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080752/
https://www.ncbi.nlm.nih.gov/pubmed/32188886
http://dx.doi.org/10.1038/s42003-020-0847-y

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