Quantifying Differences in Heritability among Psoriatic Arthritis (PsA), Cutaneous Psoriasis (PsC) and Psoriasis vulgaris (PsV)

Chronic plaque psoriasis and psoriatic arthritis are multifactorial inter-related diseases with strong genetic contributions. Better elucidation of the heritability of psoriatic disease subsets is important for identifying novel genes, risk stratification and potential clinical applications. In this...

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Autores principales: Li, Quan, Chandran, Vinod, Tsoi, Lam, O’Rielly, Darren, Nair, Rajan P., Gladman, Dafna, Elder, James T., Rahman, Proton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080781/
https://www.ncbi.nlm.nih.gov/pubmed/32188927
http://dx.doi.org/10.1038/s41598-020-61981-5
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author Li, Quan
Chandran, Vinod
Tsoi, Lam
O’Rielly, Darren
Nair, Rajan P.
Gladman, Dafna
Elder, James T.
Rahman, Proton
author_facet Li, Quan
Chandran, Vinod
Tsoi, Lam
O’Rielly, Darren
Nair, Rajan P.
Gladman, Dafna
Elder, James T.
Rahman, Proton
author_sort Li, Quan
collection PubMed
description Chronic plaque psoriasis and psoriatic arthritis are multifactorial inter-related diseases with strong genetic contributions. Better elucidation of the heritability of psoriatic disease subsets is important for identifying novel genes, risk stratification and potential clinical applications. In this study, we used two mixed-effect modelling methodologies to assess the additive contribution of common single nucleotide polymorphisms from genome-wide association studies to estimate the heritability of cutaneous psoriasis, psoriasis vulgaris and psoriatic arthritis. We found that cutaneous psoriasis and psoriatic arthritis both exhibit considerable heritability, with a greater contribution coming from cutaneous psoriasis.
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spelling pubmed-70807812020-03-23 Quantifying Differences in Heritability among Psoriatic Arthritis (PsA), Cutaneous Psoriasis (PsC) and Psoriasis vulgaris (PsV) Li, Quan Chandran, Vinod Tsoi, Lam O’Rielly, Darren Nair, Rajan P. Gladman, Dafna Elder, James T. Rahman, Proton Sci Rep Article Chronic plaque psoriasis and psoriatic arthritis are multifactorial inter-related diseases with strong genetic contributions. Better elucidation of the heritability of psoriatic disease subsets is important for identifying novel genes, risk stratification and potential clinical applications. In this study, we used two mixed-effect modelling methodologies to assess the additive contribution of common single nucleotide polymorphisms from genome-wide association studies to estimate the heritability of cutaneous psoriasis, psoriasis vulgaris and psoriatic arthritis. We found that cutaneous psoriasis and psoriatic arthritis both exhibit considerable heritability, with a greater contribution coming from cutaneous psoriasis. Nature Publishing Group UK 2020-03-18 /pmc/articles/PMC7080781/ /pubmed/32188927 http://dx.doi.org/10.1038/s41598-020-61981-5 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Li, Quan
Chandran, Vinod
Tsoi, Lam
O’Rielly, Darren
Nair, Rajan P.
Gladman, Dafna
Elder, James T.
Rahman, Proton
Quantifying Differences in Heritability among Psoriatic Arthritis (PsA), Cutaneous Psoriasis (PsC) and Psoriasis vulgaris (PsV)
title Quantifying Differences in Heritability among Psoriatic Arthritis (PsA), Cutaneous Psoriasis (PsC) and Psoriasis vulgaris (PsV)
title_full Quantifying Differences in Heritability among Psoriatic Arthritis (PsA), Cutaneous Psoriasis (PsC) and Psoriasis vulgaris (PsV)
title_fullStr Quantifying Differences in Heritability among Psoriatic Arthritis (PsA), Cutaneous Psoriasis (PsC) and Psoriasis vulgaris (PsV)
title_full_unstemmed Quantifying Differences in Heritability among Psoriatic Arthritis (PsA), Cutaneous Psoriasis (PsC) and Psoriasis vulgaris (PsV)
title_short Quantifying Differences in Heritability among Psoriatic Arthritis (PsA), Cutaneous Psoriasis (PsC) and Psoriasis vulgaris (PsV)
title_sort quantifying differences in heritability among psoriatic arthritis (psa), cutaneous psoriasis (psc) and psoriasis vulgaris (psv)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080781/
https://www.ncbi.nlm.nih.gov/pubmed/32188927
http://dx.doi.org/10.1038/s41598-020-61981-5
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