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Full-length transcript characterization of SF3B1 mutation in chronic lymphocytic leukemia reveals downregulation of retained introns

While splicing changes caused by somatic mutations in SF3B1 are known, identifying full-length isoform changes may better elucidate the functional consequences of these mutations. We report nanopore sequencing of full-length cDNA from CLL samples with and without SF3B1 mutation, as well as normal B...

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Detalles Bibliográficos
Autores principales:	Tang, Alison D., Soulette, Cameron M., van Baren, Marijke J., Hart, Kevyn, Hrabeta-Robinson, Eva, Wu, Catherine J., Brooks, Angela N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080807/ https://www.ncbi.nlm.nih.gov/pubmed/32188845 http://dx.doi.org/10.1038/s41467-020-15171-6

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