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Cx43 channels and signaling via IP(3)/Ca(2+), ATP, and ROS/NO propagate radiation-induced DNA damage to non-irradiated brain microvascular endothelial cells

Radiotherapeutic treatment consists of targeted application of radiation beams to a tumor but exposure of surrounding healthy tissue is inevitable. In the brain, ionizing radiation induces breakdown of the blood–brain barrier by effects on brain microvascular endothelial cells. Damage from directly...

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Detalles Bibliográficos
Autores principales:	Hoorelbeke, Delphine, Decrock, Elke, De Smet, Maarten, De Bock, Marijke, Descamps, Benedicte, Van Haver, Valérie, Delvaeye, Tinneke, Krysko, Dmitri V., Vanhove, Christian, Bultynck, Geert, Leybaert, Luc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080808/ https://www.ncbi.nlm.nih.gov/pubmed/32188841 http://dx.doi.org/10.1038/s41419-020-2392-5

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