Jdp2-deficient granule cell progenitors in the cerebellum are resistant to ROS-mediated apoptosis through xCT/Slc7a11 activation

The Jun dimerization protein 2 (Jdp2) is expressed predominantly in granule cell progenitors (GCPs) in the cerebellum, as was shown in Jdp2-promoter-Cre transgenic mice. Cerebellum of Jdp2-knockout (KO) mice contains lower number of Atoh-1 positive GCPs than WT. Primary cultures of GCPs from Jdp2-KO...

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Detalles Bibliográficos
Autores principales: Ku, Chia-Chen, Wuputra, Kenly, Kato, Kohsuke, Lin, Wen-Hsin, Pan, Jia-Bin, Tsai, Shih-Chieh, Kuo, Che-Jung, Lee, Kan-Hung, Lee, Yan-Liang, Lin, Ying-Chu, Saito, Shigeo, Noguchi, Michiya, Nakamura, Yukio, Miyoshi, Hiroyuki, Eckner, Richard, Nagata, Kyosuke, Wu, Deng-Chyang, Lin, Chang-Shen, Yokoyama, Kazunari K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080836/
https://www.ncbi.nlm.nih.gov/pubmed/32188872
http://dx.doi.org/10.1038/s41598-020-61692-x

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