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Hyperbaric oxygen therapy improves neurocognitive functions of post-stroke patients – a retrospective analysis
BACKGROUND: Previous studies have shown that hyperbaric oxygen therapy (HBOT) can improve the motor functions and memory of post-stroke patients in the chronic stage. OBJECTIVE: The aim of this study is to evaluate the effects of HBOT on overall cognitive functions of post-stroke patients in the chr...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOS Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081098/ https://www.ncbi.nlm.nih.gov/pubmed/31985478 http://dx.doi.org/10.3233/RNN-190959 |
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author | Hadanny, Amir Rittblat, Mor Bitterman, Mor May-Raz, Ido Suzin, Gil Boussi-Gross, Rahav Zemel, Yonatan Bechor, Yair Catalogna, Merav Efrati, Shai |
author_facet | Hadanny, Amir Rittblat, Mor Bitterman, Mor May-Raz, Ido Suzin, Gil Boussi-Gross, Rahav Zemel, Yonatan Bechor, Yair Catalogna, Merav Efrati, Shai |
author_sort | Hadanny, Amir |
collection | PubMed |
description | BACKGROUND: Previous studies have shown that hyperbaric oxygen therapy (HBOT) can improve the motor functions and memory of post-stroke patients in the chronic stage. OBJECTIVE: The aim of this study is to evaluate the effects of HBOT on overall cognitive functions of post-stroke patients in the chronic stage. The nature, type and location of the stroke were investigated as possible modifiers. METHODS: A retrospective analysis was conducted on patients who were treated with HBOT for chronic stroke (>3 months) between 2008-2018. Participants were treated in a multi-place hyperbaric chamber with the following protocols: 40 to 60 daily sessions, 5 days per week, each session included 90 min of 100% oxygen at 2 ATA with 5 min air brakes every 20 minutes. Clinically significant improvements (CSI) were defined as > 0.5 standard deviation (SD). RESULTS: The study included 162 patients (75.3% males) with a mean age of 60.75±12.91. Of them, 77(47.53%) had cortical strokes, 87(53.7%) strokes were located in the left hemisphere and 121 suffered ischemic strokes (74.6%). HBOT induced a significant increase in all the cognitive function domains (p < 0.05), with 86% of the stroke victims achieving CSI. There were no significant differences post-HBOT of cortical strokes compared to sub-cortical strokes (p > 0.05). Hemorrhagic strokes had a significantly higher improvement in information processing speed post-HBOT (p < 0.05). Left hemisphere strokes had a higher increase in the motor domain (p < 0.05). In all cognitive domains, the baseline cognitive function was a significant predictor of CSI (p < 0.05), while stroke type, location and side were not significant predictors. CONCLUSIONS: HBOT induces significant improvements in all cognitive domains even in the late chronic stage. The selection of post-stroke patients for HBOT should be based on functional analysis and baseline cognitive scores rather than the stroke type, location or side of lesion. |
format | Online Article Text |
id | pubmed-7081098 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | IOS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-70810982020-03-23 Hyperbaric oxygen therapy improves neurocognitive functions of post-stroke patients – a retrospective analysis Hadanny, Amir Rittblat, Mor Bitterman, Mor May-Raz, Ido Suzin, Gil Boussi-Gross, Rahav Zemel, Yonatan Bechor, Yair Catalogna, Merav Efrati, Shai Restor Neurol Neurosci Research Article BACKGROUND: Previous studies have shown that hyperbaric oxygen therapy (HBOT) can improve the motor functions and memory of post-stroke patients in the chronic stage. OBJECTIVE: The aim of this study is to evaluate the effects of HBOT on overall cognitive functions of post-stroke patients in the chronic stage. The nature, type and location of the stroke were investigated as possible modifiers. METHODS: A retrospective analysis was conducted on patients who were treated with HBOT for chronic stroke (>3 months) between 2008-2018. Participants were treated in a multi-place hyperbaric chamber with the following protocols: 40 to 60 daily sessions, 5 days per week, each session included 90 min of 100% oxygen at 2 ATA with 5 min air brakes every 20 minutes. Clinically significant improvements (CSI) were defined as > 0.5 standard deviation (SD). RESULTS: The study included 162 patients (75.3% males) with a mean age of 60.75±12.91. Of them, 77(47.53%) had cortical strokes, 87(53.7%) strokes were located in the left hemisphere and 121 suffered ischemic strokes (74.6%). HBOT induced a significant increase in all the cognitive function domains (p < 0.05), with 86% of the stroke victims achieving CSI. There were no significant differences post-HBOT of cortical strokes compared to sub-cortical strokes (p > 0.05). Hemorrhagic strokes had a significantly higher improvement in information processing speed post-HBOT (p < 0.05). Left hemisphere strokes had a higher increase in the motor domain (p < 0.05). In all cognitive domains, the baseline cognitive function was a significant predictor of CSI (p < 0.05), while stroke type, location and side were not significant predictors. CONCLUSIONS: HBOT induces significant improvements in all cognitive domains even in the late chronic stage. The selection of post-stroke patients for HBOT should be based on functional analysis and baseline cognitive scores rather than the stroke type, location or side of lesion. IOS Press 2020-02-11 /pmc/articles/PMC7081098/ /pubmed/31985478 http://dx.doi.org/10.3233/RNN-190959 Text en © 2020 – IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Hadanny, Amir Rittblat, Mor Bitterman, Mor May-Raz, Ido Suzin, Gil Boussi-Gross, Rahav Zemel, Yonatan Bechor, Yair Catalogna, Merav Efrati, Shai Hyperbaric oxygen therapy improves neurocognitive functions of post-stroke patients – a retrospective analysis |
title | Hyperbaric oxygen therapy improves neurocognitive functions of post-stroke patients – a retrospective analysis |
title_full | Hyperbaric oxygen therapy improves neurocognitive functions of post-stroke patients – a retrospective analysis |
title_fullStr | Hyperbaric oxygen therapy improves neurocognitive functions of post-stroke patients – a retrospective analysis |
title_full_unstemmed | Hyperbaric oxygen therapy improves neurocognitive functions of post-stroke patients – a retrospective analysis |
title_short | Hyperbaric oxygen therapy improves neurocognitive functions of post-stroke patients – a retrospective analysis |
title_sort | hyperbaric oxygen therapy improves neurocognitive functions of post-stroke patients – a retrospective analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081098/ https://www.ncbi.nlm.nih.gov/pubmed/31985478 http://dx.doi.org/10.3233/RNN-190959 |
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