Cargando…
Surgical intervention for malignant bowel obstruction caused by gastrointestinal malignancies
BACKGROUND: Malignant bowel obstruction (MBO) is a common event for end-stage gastrointestinal cancer patients. Previous studies had demonstrated manifestations and clinical management of MBO with mixed malignancies. There still lack reports of the surgical treatment of MBO. AIM: To analyze the shor...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081110/ https://www.ncbi.nlm.nih.gov/pubmed/32206182 http://dx.doi.org/10.4251/wjgo.v12.i3.323 |
_version_ | 1783508116745224192 |
---|---|
author | Chen, Peng-Ju Wang, Lin Peng, Yi-Fan Chen, Nan Wu, Ai-Wen |
author_facet | Chen, Peng-Ju Wang, Lin Peng, Yi-Fan Chen, Nan Wu, Ai-Wen |
author_sort | Chen, Peng-Ju |
collection | PubMed |
description | BACKGROUND: Malignant bowel obstruction (MBO) is a common event for end-stage gastrointestinal cancer patients. Previous studies had demonstrated manifestations and clinical management of MBO with mixed malignancies. There still lack reports of the surgical treatment of MBO. AIM: To analyze the short-term outcomes and prognosis of palliative surgery for MBO caused by gastrointestinal cancer. METHODS: A retrospective chart review of 61 patients received palliative surgery between January 2016 to October 2018 was performed, of which 31 patients underwent massive debulking surgery (MDS) and 30 underwent ostomy/by-pass surgery (OBS). The 60-d symptom palliation rate, 30-d morbidity and mortality, and overall survival rates were compared between the two groups. RESULTS: The overall symptom palliation rate was 75.4% (46/61); patients in the MDS group had significantly higher symptom palliation rate than OBS group (90% vs 61.2%, P = 0.016). Patients with colorectal cancer who were in the MDS group showed significantly higher symptom improvement rates compared to the OBS group (overall, 76.4%; MDS, 61.5%; OBS, 92%; P = 0.019). However, patients with gastric cancer did not show a significant difference in symptom palliation rate between the MDS and OBS groups (OBS, 60%; MDS, 80%; P = 1.0). The median survival time in the MDS group was significantly longer than in the OBS group (10.9 mo vs 5.3 mo, P = 0.05). CONCLUSION: For patients with MBO caused by peritoneal metastatic colorectal cancer, MDS can improve symptom palliation rates and prolong survival, without increasing mortality and morbidity rates. |
format | Online Article Text |
id | pubmed-7081110 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-70811102020-03-23 Surgical intervention for malignant bowel obstruction caused by gastrointestinal malignancies Chen, Peng-Ju Wang, Lin Peng, Yi-Fan Chen, Nan Wu, Ai-Wen World J Gastrointest Oncol Retrospective Study BACKGROUND: Malignant bowel obstruction (MBO) is a common event for end-stage gastrointestinal cancer patients. Previous studies had demonstrated manifestations and clinical management of MBO with mixed malignancies. There still lack reports of the surgical treatment of MBO. AIM: To analyze the short-term outcomes and prognosis of palliative surgery for MBO caused by gastrointestinal cancer. METHODS: A retrospective chart review of 61 patients received palliative surgery between January 2016 to October 2018 was performed, of which 31 patients underwent massive debulking surgery (MDS) and 30 underwent ostomy/by-pass surgery (OBS). The 60-d symptom palliation rate, 30-d morbidity and mortality, and overall survival rates were compared between the two groups. RESULTS: The overall symptom palliation rate was 75.4% (46/61); patients in the MDS group had significantly higher symptom palliation rate than OBS group (90% vs 61.2%, P = 0.016). Patients with colorectal cancer who were in the MDS group showed significantly higher symptom improvement rates compared to the OBS group (overall, 76.4%; MDS, 61.5%; OBS, 92%; P = 0.019). However, patients with gastric cancer did not show a significant difference in symptom palliation rate between the MDS and OBS groups (OBS, 60%; MDS, 80%; P = 1.0). The median survival time in the MDS group was significantly longer than in the OBS group (10.9 mo vs 5.3 mo, P = 0.05). CONCLUSION: For patients with MBO caused by peritoneal metastatic colorectal cancer, MDS can improve symptom palliation rates and prolong survival, without increasing mortality and morbidity rates. Baishideng Publishing Group Inc 2020-03-15 2020-03-15 /pmc/articles/PMC7081110/ /pubmed/32206182 http://dx.doi.org/10.4251/wjgo.v12.i3.323 Text en ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Retrospective Study Chen, Peng-Ju Wang, Lin Peng, Yi-Fan Chen, Nan Wu, Ai-Wen Surgical intervention for malignant bowel obstruction caused by gastrointestinal malignancies |
title | Surgical intervention for malignant bowel obstruction caused by gastrointestinal malignancies |
title_full | Surgical intervention for malignant bowel obstruction caused by gastrointestinal malignancies |
title_fullStr | Surgical intervention for malignant bowel obstruction caused by gastrointestinal malignancies |
title_full_unstemmed | Surgical intervention for malignant bowel obstruction caused by gastrointestinal malignancies |
title_short | Surgical intervention for malignant bowel obstruction caused by gastrointestinal malignancies |
title_sort | surgical intervention for malignant bowel obstruction caused by gastrointestinal malignancies |
topic | Retrospective Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081110/ https://www.ncbi.nlm.nih.gov/pubmed/32206182 http://dx.doi.org/10.4251/wjgo.v12.i3.323 |
work_keys_str_mv | AT chenpengju surgicalinterventionformalignantbowelobstructioncausedbygastrointestinalmalignancies AT wanglin surgicalinterventionformalignantbowelobstructioncausedbygastrointestinalmalignancies AT pengyifan surgicalinterventionformalignantbowelobstructioncausedbygastrointestinalmalignancies AT chennan surgicalinterventionformalignantbowelobstructioncausedbygastrointestinalmalignancies AT wuaiwen surgicalinterventionformalignantbowelobstructioncausedbygastrointestinalmalignancies |