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Impact of preoperative chemoradiotherapy using concurrent S-1 and CPT-11 on long-term clinical outcomes in locally advanced rectal cancer

BACKGROUND: Preoperative chemoradiotherapy regimens using a second drug for locally advanced rectal cancer are still under clinical investigation. AIM: To investigate the clinical outcomes of patients with locally advanced rectal cancer treated with preoperative chemoradiotherapy using tegafur/gimer...

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Autores principales: Kimura, Kei, Beppu, Naohito, Doi, Hiroshi, Kataoka, Kozo, Yamano, Tomoki, Uchino, Motoi, Ikeda, Masataka, Ikeuchi, Hiroki, Tomita, Naohiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081115/
https://www.ncbi.nlm.nih.gov/pubmed/32206181
http://dx.doi.org/10.4251/wjgo.v12.i3.311
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author Kimura, Kei
Beppu, Naohito
Doi, Hiroshi
Kataoka, Kozo
Yamano, Tomoki
Uchino, Motoi
Ikeda, Masataka
Ikeuchi, Hiroki
Tomita, Naohiro
author_facet Kimura, Kei
Beppu, Naohito
Doi, Hiroshi
Kataoka, Kozo
Yamano, Tomoki
Uchino, Motoi
Ikeda, Masataka
Ikeuchi, Hiroki
Tomita, Naohiro
author_sort Kimura, Kei
collection PubMed
description BACKGROUND: Preoperative chemoradiotherapy regimens using a second drug for locally advanced rectal cancer are still under clinical investigation. AIM: To investigate the clinical outcomes of patients with locally advanced rectal cancer treated with preoperative chemoradiotherapy using tegafur/gimeracil/oteracil (S-1) plus irinotecan (CPT-11). METHODS: This was a single-center retrospective study of 82 patients who underwent radical surgery for rectal cancer after chemoradiotherapy with S-1 (80 mg/m(2)/d), CPT-11 (60 mg/m(2)/d), and radiation (total 45 Gy) between 2009 and 2016. The median follow-up was 51 mo (range: 17–116 mo). RESULTS: Twenty-nine patients (35.4%) had T3 or T4 rectal cancer with mesorectal fascia invasion, 36 (43.9%) had extramural vascular invasion, 24 (29.8%) had N2 rectal cancer and eight (9.8%) had lateral lymph node swelling. The relative dose intensity was 90.1% for S-1 and 92.9% for CPT-11. Seventy-nine patients (96.3%) underwent R0 resection. With regard to pathological response, 13 patients (15.9%) had a pathological complete response and 52 (63.4%) a good response (tumor regression grade 2/3). The 5-year local recurrence-free survival, relapse-free survival and overall survival rates were 90.1%, 72.5% and 91.3%, respectively. We analyzed the risk factors for local recurrence-free survival by Cox regression analysis and none were detected. Previously described risk factors such as T4 stage, mesorectal fascia invasion or lateral lymph node swelling were not detected as negative factors for local recurrence-free survival. CONCLUSION: We demonstrated good compliance and favorable tumor regression in patients with locally advanced rectal cancer treated with preoperative S-1 and CPT-11.
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spelling pubmed-70811152020-03-23 Impact of preoperative chemoradiotherapy using concurrent S-1 and CPT-11 on long-term clinical outcomes in locally advanced rectal cancer Kimura, Kei Beppu, Naohito Doi, Hiroshi Kataoka, Kozo Yamano, Tomoki Uchino, Motoi Ikeda, Masataka Ikeuchi, Hiroki Tomita, Naohiro World J Gastrointest Oncol Retrospective Study BACKGROUND: Preoperative chemoradiotherapy regimens using a second drug for locally advanced rectal cancer are still under clinical investigation. AIM: To investigate the clinical outcomes of patients with locally advanced rectal cancer treated with preoperative chemoradiotherapy using tegafur/gimeracil/oteracil (S-1) plus irinotecan (CPT-11). METHODS: This was a single-center retrospective study of 82 patients who underwent radical surgery for rectal cancer after chemoradiotherapy with S-1 (80 mg/m(2)/d), CPT-11 (60 mg/m(2)/d), and radiation (total 45 Gy) between 2009 and 2016. The median follow-up was 51 mo (range: 17–116 mo). RESULTS: Twenty-nine patients (35.4%) had T3 or T4 rectal cancer with mesorectal fascia invasion, 36 (43.9%) had extramural vascular invasion, 24 (29.8%) had N2 rectal cancer and eight (9.8%) had lateral lymph node swelling. The relative dose intensity was 90.1% for S-1 and 92.9% for CPT-11. Seventy-nine patients (96.3%) underwent R0 resection. With regard to pathological response, 13 patients (15.9%) had a pathological complete response and 52 (63.4%) a good response (tumor regression grade 2/3). The 5-year local recurrence-free survival, relapse-free survival and overall survival rates were 90.1%, 72.5% and 91.3%, respectively. We analyzed the risk factors for local recurrence-free survival by Cox regression analysis and none were detected. Previously described risk factors such as T4 stage, mesorectal fascia invasion or lateral lymph node swelling were not detected as negative factors for local recurrence-free survival. CONCLUSION: We demonstrated good compliance and favorable tumor regression in patients with locally advanced rectal cancer treated with preoperative S-1 and CPT-11. Baishideng Publishing Group Inc 2020-03-15 2020-03-15 /pmc/articles/PMC7081115/ /pubmed/32206181 http://dx.doi.org/10.4251/wjgo.v12.i3.311 Text en ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Retrospective Study
Kimura, Kei
Beppu, Naohito
Doi, Hiroshi
Kataoka, Kozo
Yamano, Tomoki
Uchino, Motoi
Ikeda, Masataka
Ikeuchi, Hiroki
Tomita, Naohiro
Impact of preoperative chemoradiotherapy using concurrent S-1 and CPT-11 on long-term clinical outcomes in locally advanced rectal cancer
title Impact of preoperative chemoradiotherapy using concurrent S-1 and CPT-11 on long-term clinical outcomes in locally advanced rectal cancer
title_full Impact of preoperative chemoradiotherapy using concurrent S-1 and CPT-11 on long-term clinical outcomes in locally advanced rectal cancer
title_fullStr Impact of preoperative chemoradiotherapy using concurrent S-1 and CPT-11 on long-term clinical outcomes in locally advanced rectal cancer
title_full_unstemmed Impact of preoperative chemoradiotherapy using concurrent S-1 and CPT-11 on long-term clinical outcomes in locally advanced rectal cancer
title_short Impact of preoperative chemoradiotherapy using concurrent S-1 and CPT-11 on long-term clinical outcomes in locally advanced rectal cancer
title_sort impact of preoperative chemoradiotherapy using concurrent s-1 and cpt-11 on long-term clinical outcomes in locally advanced rectal cancer
topic Retrospective Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081115/
https://www.ncbi.nlm.nih.gov/pubmed/32206181
http://dx.doi.org/10.4251/wjgo.v12.i3.311
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