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Mixtures of prion substrains in natural scrapie cases revealed by ovinised murine models

Phenotypic variability in prion diseases, such as scrapie, is associated to the existence of prion strains, which are different pathogenic prion protein (PrP(Sc)) conformations with distinct pathobiological properties. To faithfully study scrapie strain variability in natural sheep isolates, transge...

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Detalles Bibliográficos
Autores principales:	Barrio, Tomás, Filali, Hicham, Otero, Alicia, Sheleby-Elías, Jessica, Marín, Belén, Vidal, Enric, Béringue, Vincent, Torres, Juan María, Groschup, Martin, Andréoletti, Olivier, Badiola, Juan José, Bolea, Rosa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081250/ https://www.ncbi.nlm.nih.gov/pubmed/32193445 http://dx.doi.org/10.1038/s41598-020-61977-1

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