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Time-resolved cathodoluminescence of DNA triggered by picosecond electron bunches

Despite the tremendous importance of so-called ionizing radiations (X-rays, accelerated electrons and ions) in cancer treatment, most studies on their effects have focused on the ionization process itself, and neglect the excitation events the radiations can induce. Here, we show that the excited st...

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Autores principales: Renault, Jean Philippe, Lucas, Bruno, Gustavsson, Thomas, Huetz, Alain, Oksenhendler, Thomas, Staicu-Casagrande, Elena-Magdalena, Géléoc, Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081262/
https://www.ncbi.nlm.nih.gov/pubmed/32193504
http://dx.doi.org/10.1038/s41598-020-61711-x
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author Renault, Jean Philippe
Lucas, Bruno
Gustavsson, Thomas
Huetz, Alain
Oksenhendler, Thomas
Staicu-Casagrande, Elena-Magdalena
Géléoc, Marie
author_facet Renault, Jean Philippe
Lucas, Bruno
Gustavsson, Thomas
Huetz, Alain
Oksenhendler, Thomas
Staicu-Casagrande, Elena-Magdalena
Géléoc, Marie
author_sort Renault, Jean Philippe
collection PubMed
description Despite the tremendous importance of so-called ionizing radiations (X-rays, accelerated electrons and ions) in cancer treatment, most studies on their effects have focused on the ionization process itself, and neglect the excitation events the radiations can induce. Here, we show that the excited states of DNA exposed to accelerated electrons can be studied in the picosecond time domain using a recently developed cathodoluminescence system with high temporal resolution. Our study uses a table-top ultrafast, UV laser-triggered electron gun delivering picosecond electron bunches of keV energy. This scheme makes it possible to directly compare time-resolved cathodoluminescence with photoluminescence measurements. This comparison revealed qualitative differences, as well as quantitative similarities between excited states of DNA upon exposure to electrons or photons.
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spelling pubmed-70812622020-03-23 Time-resolved cathodoluminescence of DNA triggered by picosecond electron bunches Renault, Jean Philippe Lucas, Bruno Gustavsson, Thomas Huetz, Alain Oksenhendler, Thomas Staicu-Casagrande, Elena-Magdalena Géléoc, Marie Sci Rep Article Despite the tremendous importance of so-called ionizing radiations (X-rays, accelerated electrons and ions) in cancer treatment, most studies on their effects have focused on the ionization process itself, and neglect the excitation events the radiations can induce. Here, we show that the excited states of DNA exposed to accelerated electrons can be studied in the picosecond time domain using a recently developed cathodoluminescence system with high temporal resolution. Our study uses a table-top ultrafast, UV laser-triggered electron gun delivering picosecond electron bunches of keV energy. This scheme makes it possible to directly compare time-resolved cathodoluminescence with photoluminescence measurements. This comparison revealed qualitative differences, as well as quantitative similarities between excited states of DNA upon exposure to electrons or photons. Nature Publishing Group UK 2020-03-19 /pmc/articles/PMC7081262/ /pubmed/32193504 http://dx.doi.org/10.1038/s41598-020-61711-x Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Renault, Jean Philippe
Lucas, Bruno
Gustavsson, Thomas
Huetz, Alain
Oksenhendler, Thomas
Staicu-Casagrande, Elena-Magdalena
Géléoc, Marie
Time-resolved cathodoluminescence of DNA triggered by picosecond electron bunches
title Time-resolved cathodoluminescence of DNA triggered by picosecond electron bunches
title_full Time-resolved cathodoluminescence of DNA triggered by picosecond electron bunches
title_fullStr Time-resolved cathodoluminescence of DNA triggered by picosecond electron bunches
title_full_unstemmed Time-resolved cathodoluminescence of DNA triggered by picosecond electron bunches
title_short Time-resolved cathodoluminescence of DNA triggered by picosecond electron bunches
title_sort time-resolved cathodoluminescence of dna triggered by picosecond electron bunches
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081262/
https://www.ncbi.nlm.nih.gov/pubmed/32193504
http://dx.doi.org/10.1038/s41598-020-61711-x
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