IGFBP-3 Blocks Hyaluronan-CD44 Signaling, Leading to Increased Acetylcholinesterase Levels in A549 Cell Media and Apoptosis in a p53-Dependent Manner

Insulin-like growth factor binding protein-3 (IGFBP-3) belongs to a family of six IGF binding proteins. We previously found that IGFBP-3 exerts its cytotoxic effects on A549 (p53 wild-type) cell survival through a mechanism that depends on hyaluronan-CD44 interactions. To shed light on the mechanism...

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Detalles Bibliográficos
Autores principales: Price, Deanna, Muterspaugh, Robert, Clegg, Bradley, Williams, Asana, Stephens, Alexis, Guthrie, Jeffrey, Heyl, Deborah, Evans, Hedeel Guy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081274/
https://www.ncbi.nlm.nih.gov/pubmed/32193421
http://dx.doi.org/10.1038/s41598-020-61743-3

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