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Induced DNA hypomethylation by Folic Acid Deprivation in Bovine Fibroblast Donor Cells Improves Reprogramming of Somatic Cell Nuclear Transfer Embryos

Aberrant patterns of DNA methylation are consistent events in SCNT derived embryos and mechanistically are believed to be related to abnormal development. While some epigenetic drugs have been used in attempts to improve SCNT efficiency but some concerns remained toward the safety of these drugs on...

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Detalles Bibliográficos
Autores principales:	Jozi, Mina, Jafarpour, Farnoosh, Moradi, Reza, Zadegan, Faezeh Ghazvini, Karbalaie, Khadijeh, Nasr-Esfahani, Mohammad Hossein
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081283/ https://www.ncbi.nlm.nih.gov/pubmed/32193457 http://dx.doi.org/10.1038/s41598-020-61797-3

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