Inhibition of the Yersinia pestis Methylerythritol Phosphate Pathway of Isoprenoid Biosynthesis by α-Phenyl-Substituted Reverse Fosmidomycin Analogues

[Image: see text] Fosmidomycin inhibits IspC (1-deoxy-d-xylulose 5-phosphate reductoisomerase), the first committed enzyme in the methylerythritol phosphate (MEP) pathway of isoprenoid biosynthesis. The MEP pathway of isoprenoid biosynthesis is essential to the causative agent of the plague, Yersini...

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Detalles Bibliográficos
Autores principales: Ball, Haley S., Girma, Misgina, Zainab, Mosufa, Riley, Honoria, Behrendt, Christoph T., Lienau, Claudia, Konzuch, Sarah, Avelar, Leandro A. A., Lungerich, Beate, Soojhawon, Iswarduth, Noble, Schroeder M., Kurz, Thomas, Couch, Robin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081406/
https://www.ncbi.nlm.nih.gov/pubmed/32201804
http://dx.doi.org/10.1021/acsomega.9b04171

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