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Increased respiratory morbidity in individuals with interstitial lung abnormalities
BACKGROUND: Interstitial lung abnormalities (ILA) are common in participants of lung cancer screening trials and broad population-based cohorts. They are associated with increased mortality, but less is known about disease specific morbidity and healthcare utilisation in individuals with ILA. METHOD...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081690/ https://www.ncbi.nlm.nih.gov/pubmed/32188453 http://dx.doi.org/10.1186/s12890-020-1107-0 |
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author | Hoyer, Nils Thomsen, Laura H. Wille, Mathilde M. W. Wilcke, Torgny Dirksen, Asger Pedersen, Jesper H. Saghir, Zaigham Ashraf, Haseem Shaker, Saher B. |
author_facet | Hoyer, Nils Thomsen, Laura H. Wille, Mathilde M. W. Wilcke, Torgny Dirksen, Asger Pedersen, Jesper H. Saghir, Zaigham Ashraf, Haseem Shaker, Saher B. |
author_sort | Hoyer, Nils |
collection | PubMed |
description | BACKGROUND: Interstitial lung abnormalities (ILA) are common in participants of lung cancer screening trials and broad population-based cohorts. They are associated with increased mortality, but less is known about disease specific morbidity and healthcare utilisation in individuals with ILA. METHODS: We included all participants from the screening arm of the Danish Lung Cancer Screening Trial with available baseline CT scan data (n = 1990) in this cohort study. The baseline scan was scored for the presence of ILA and patients were followed for up to 12 years. Data about all hospital admissions, primary healthcare visits and medicine prescriptions were collected from the Danish National Health Registries and used to determine the participants’ disease specific morbidity and healthcare utilisation using Cox proportional hazards models. RESULTS: The 332 (16.7%) participants with ILA were more likely to be diagnosed with one of several respiratory diseases, including interstitial lung disease (HR: 4.9, 95% CI: 1.8–13.3, p = 0.008), COPD (HR: 1.7, 95% CI: 1.2–2.3, p = 0.01), pneumonia (HR: 2.0, 95% CI: 1.4–2.7, p < 0.001), lung cancer (HR: 2.7, 95% CI: 1.8–4.0, p < 0.001) and respiratory failure (HR: 1.8, 95% CI: 1.1–3.0, p = 0.03) compared with participants without ILA. These findings were confirmed by increased hospital admission rates with these diagnoses and more frequent prescriptions for inhalation medicine and antibiotics in participants with ILA. CONCLUSIONS: Individuals with ILA are more likely to receive a diagnosis and treatment for several respiratory diseases, including interstitial lung disease, COPD, pneumonia, lung cancer and respiratory failure during long-term follow-up. |
format | Online Article Text |
id | pubmed-7081690 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-70816902020-03-23 Increased respiratory morbidity in individuals with interstitial lung abnormalities Hoyer, Nils Thomsen, Laura H. Wille, Mathilde M. W. Wilcke, Torgny Dirksen, Asger Pedersen, Jesper H. Saghir, Zaigham Ashraf, Haseem Shaker, Saher B. BMC Pulm Med Research Article BACKGROUND: Interstitial lung abnormalities (ILA) are common in participants of lung cancer screening trials and broad population-based cohorts. They are associated with increased mortality, but less is known about disease specific morbidity and healthcare utilisation in individuals with ILA. METHODS: We included all participants from the screening arm of the Danish Lung Cancer Screening Trial with available baseline CT scan data (n = 1990) in this cohort study. The baseline scan was scored for the presence of ILA and patients were followed for up to 12 years. Data about all hospital admissions, primary healthcare visits and medicine prescriptions were collected from the Danish National Health Registries and used to determine the participants’ disease specific morbidity and healthcare utilisation using Cox proportional hazards models. RESULTS: The 332 (16.7%) participants with ILA were more likely to be diagnosed with one of several respiratory diseases, including interstitial lung disease (HR: 4.9, 95% CI: 1.8–13.3, p = 0.008), COPD (HR: 1.7, 95% CI: 1.2–2.3, p = 0.01), pneumonia (HR: 2.0, 95% CI: 1.4–2.7, p < 0.001), lung cancer (HR: 2.7, 95% CI: 1.8–4.0, p < 0.001) and respiratory failure (HR: 1.8, 95% CI: 1.1–3.0, p = 0.03) compared with participants without ILA. These findings were confirmed by increased hospital admission rates with these diagnoses and more frequent prescriptions for inhalation medicine and antibiotics in participants with ILA. CONCLUSIONS: Individuals with ILA are more likely to receive a diagnosis and treatment for several respiratory diseases, including interstitial lung disease, COPD, pneumonia, lung cancer and respiratory failure during long-term follow-up. BioMed Central 2020-03-19 /pmc/articles/PMC7081690/ /pubmed/32188453 http://dx.doi.org/10.1186/s12890-020-1107-0 Text en © The Author(s). 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Hoyer, Nils Thomsen, Laura H. Wille, Mathilde M. W. Wilcke, Torgny Dirksen, Asger Pedersen, Jesper H. Saghir, Zaigham Ashraf, Haseem Shaker, Saher B. Increased respiratory morbidity in individuals with interstitial lung abnormalities |
title | Increased respiratory morbidity in individuals with interstitial lung abnormalities |
title_full | Increased respiratory morbidity in individuals with interstitial lung abnormalities |
title_fullStr | Increased respiratory morbidity in individuals with interstitial lung abnormalities |
title_full_unstemmed | Increased respiratory morbidity in individuals with interstitial lung abnormalities |
title_short | Increased respiratory morbidity in individuals with interstitial lung abnormalities |
title_sort | increased respiratory morbidity in individuals with interstitial lung abnormalities |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081690/ https://www.ncbi.nlm.nih.gov/pubmed/32188453 http://dx.doi.org/10.1186/s12890-020-1107-0 |
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