Characterization and applications of chimeric mice with humanized livers for preclinical drug development

We have succeeded in stable mass production of chimeric PXB-mice, whose liver is repopulated by human hepatocytes at a ratio of more than 70%, and we are providing these mice to academia and pharmaceutical companies to support the development of new drugs or studies of liver function. Furthermore, w...

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Detalles Bibliográficos
Autores principales: Tateno, Chise, Kojima, Yuha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081693/
https://www.ncbi.nlm.nih.gov/pubmed/32206609
http://dx.doi.org/10.1186/s42826-019-0032-y
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author Tateno, Chise
Kojima, Yuha
author_facet Tateno, Chise
Kojima, Yuha
author_sort Tateno, Chise
collection PubMed
description We have succeeded in stable mass production of chimeric PXB-mice, whose liver is repopulated by human hepatocytes at a ratio of more than 70%, and we are providing these mice to academia and pharmaceutical companies to support the development of new drugs or studies of liver function. Furthermore, we isolated human hepatocytes, called PXB-cells, from the chimeric mice, and provide them for clients weekly for in vitro studies. In this review, we summarize the existing characterizations of PXB-mice and PXB-cells and their present and future applications.
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spelling pubmed-70816932020-03-23 Characterization and applications of chimeric mice with humanized livers for preclinical drug development Tateno, Chise Kojima, Yuha Lab Anim Res Review We have succeeded in stable mass production of chimeric PXB-mice, whose liver is repopulated by human hepatocytes at a ratio of more than 70%, and we are providing these mice to academia and pharmaceutical companies to support the development of new drugs or studies of liver function. Furthermore, we isolated human hepatocytes, called PXB-cells, from the chimeric mice, and provide them for clients weekly for in vitro studies. In this review, we summarize the existing characterizations of PXB-mice and PXB-cells and their present and future applications. BioMed Central 2020-01-08 /pmc/articles/PMC7081693/ /pubmed/32206609 http://dx.doi.org/10.1186/s42826-019-0032-y Text en © The Author(s) 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Tateno, Chise
Kojima, Yuha
Characterization and applications of chimeric mice with humanized livers for preclinical drug development
title Characterization and applications of chimeric mice with humanized livers for preclinical drug development
title_full Characterization and applications of chimeric mice with humanized livers for preclinical drug development
title_fullStr Characterization and applications of chimeric mice with humanized livers for preclinical drug development
title_full_unstemmed Characterization and applications of chimeric mice with humanized livers for preclinical drug development
title_short Characterization and applications of chimeric mice with humanized livers for preclinical drug development
title_sort characterization and applications of chimeric mice with humanized livers for preclinical drug development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081693/
https://www.ncbi.nlm.nih.gov/pubmed/32206609
http://dx.doi.org/10.1186/s42826-019-0032-y
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