Alterations in the methylome of the stromal tumour microenvironment signal the presence and severity of prostate cancer

BACKGROUND: Prostate cancer changes the phenotype of cells within the stromal microenvironment, including fibroblasts, which in turn promote tumour progression. Functional changes in prostate cancer-associated fibroblasts (CAFs) coincide with alterations in DNA methylation levels at loci-specific re...

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Detalles Bibliográficos
Autores principales: Lawrence, Mitchell G., Pidsley, Ruth, Niranjan, Birunthi, Papargiris, Melissa, Pereira, Brooke A., Richards, Michelle, Teng, Linda, Norden, Sam, Ryan, Andrew, Frydenberg, Mark, Stirzaker, Clare, Taylor, Renea A., Risbridger, Gail P., Clark, Susan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081708/
https://www.ncbi.nlm.nih.gov/pubmed/32188493
http://dx.doi.org/10.1186/s13148-020-00836-2

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