Methylome-based cell-of-origin modeling (Methyl-COOM) identifies aberrant expression of immune regulatory molecules in CLL

BACKGROUND: In cancer, normal epigenetic patterns are disturbed and contribute to gene expression changes, disease onset, and progression. The cancer epigenome is composed of the epigenetic patterns present in the tumor-initiating cell at the time of transformation, and the tumor-specific epigenetic...

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Detalles Bibliográficos
Autores principales: Wierzbinska, Justyna A., Toth, Reka, Ishaque, Naveed, Rippe, Karsten, Mallm, Jan-Philipp, Klett, Lara C., Mertens, Daniel, Zenz, Thorsten, Hielscher, Thomas, Seifert, Marc, Küppers, Ralf, Assenov, Yassen, Lutsik, Pavlo, Stilgenbauer, Stephan, Roessner, Philipp M., Seiffert, Martina, Byrd, John, Oakes, Christopher C., Plass, Christoph, Lipka, Daniel B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081711/
https://www.ncbi.nlm.nih.gov/pubmed/32188505
http://dx.doi.org/10.1186/s13073-020-00724-7

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