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Tumor microenvironment predicts local tumor extensiveness in PD-L1 positive nasopharyngeal cancer

Tumor microenvironment have been implicated in many kind of cancers to hold an important role in determining treatment success especially with immunotherapy. In nasopharyngeal cancer, the prognostic role of this immune cells within tumor microenvironment is still doubtful. We conducted a study that...

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Autores principales: Gondhowiardjo, Soehartati A., Handoko, Adham, Marlinda, Rachmadi, Lisnawati, Kodrat, Henry, Tobing, Demak Lumban, Haryoga, I. Made, Dwiyono, Agustinus Gatot, Kristian, Yoseph Adi, Mayang Permata, Tiara Bunga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082005/
https://www.ncbi.nlm.nih.gov/pubmed/32191754
http://dx.doi.org/10.1371/journal.pone.0230449
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author Gondhowiardjo, Soehartati A.
Handoko,
Adham, Marlinda
Rachmadi, Lisnawati
Kodrat, Henry
Tobing, Demak Lumban
Haryoga, I. Made
Dwiyono, Agustinus Gatot
Kristian, Yoseph Adi
Mayang Permata, Tiara Bunga
author_facet Gondhowiardjo, Soehartati A.
Handoko,
Adham, Marlinda
Rachmadi, Lisnawati
Kodrat, Henry
Tobing, Demak Lumban
Haryoga, I. Made
Dwiyono, Agustinus Gatot
Kristian, Yoseph Adi
Mayang Permata, Tiara Bunga
author_sort Gondhowiardjo, Soehartati A.
collection PubMed
description Tumor microenvironment have been implicated in many kind of cancers to hold an important role in determining treatment success especially with immunotherapy. In nasopharyngeal cancer, the prognostic role of this immune cells within tumor microenvironment is still doubtful. We conducted a study that included 25 nasopharyngeal cancer biopsy specimens to seek a more direct relationship between tumor infiltrating immune cells and tumor progression. Apart from that, we also checked the PD-L1 protein through immunohistochemistry. The PD-L1 was positively expressed in all our 25 samples with nasopharyngeal cancer WHO type 3 histology. Majority samples have >50% PD-L1 expression in tumor cells. We also found that denser local tumor infiltrating immune cells population have relatively much smaller local tumor volume. The inverse applied, with the mean local tumor volumes were 181.92 cm(3) ± 81.45 cm(3), 117.13 cm(3) ± 88.72 cm(3), and 55.13 cm(3) ± 25.06 cm(3) for mild, moderate, and heavy immune cells infiltration respectively (p = 0.013). Therefore, we concluded that tumor infiltrating immune cells play an important role in tumor progression, hence evaluating this simple and predictive factor may provide us with some valuable prognostic information.
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spelling pubmed-70820052020-03-24 Tumor microenvironment predicts local tumor extensiveness in PD-L1 positive nasopharyngeal cancer Gondhowiardjo, Soehartati A. Handoko, Adham, Marlinda Rachmadi, Lisnawati Kodrat, Henry Tobing, Demak Lumban Haryoga, I. Made Dwiyono, Agustinus Gatot Kristian, Yoseph Adi Mayang Permata, Tiara Bunga PLoS One Research Article Tumor microenvironment have been implicated in many kind of cancers to hold an important role in determining treatment success especially with immunotherapy. In nasopharyngeal cancer, the prognostic role of this immune cells within tumor microenvironment is still doubtful. We conducted a study that included 25 nasopharyngeal cancer biopsy specimens to seek a more direct relationship between tumor infiltrating immune cells and tumor progression. Apart from that, we also checked the PD-L1 protein through immunohistochemistry. The PD-L1 was positively expressed in all our 25 samples with nasopharyngeal cancer WHO type 3 histology. Majority samples have >50% PD-L1 expression in tumor cells. We also found that denser local tumor infiltrating immune cells population have relatively much smaller local tumor volume. The inverse applied, with the mean local tumor volumes were 181.92 cm(3) ± 81.45 cm(3), 117.13 cm(3) ± 88.72 cm(3), and 55.13 cm(3) ± 25.06 cm(3) for mild, moderate, and heavy immune cells infiltration respectively (p = 0.013). Therefore, we concluded that tumor infiltrating immune cells play an important role in tumor progression, hence evaluating this simple and predictive factor may provide us with some valuable prognostic information. Public Library of Science 2020-03-19 /pmc/articles/PMC7082005/ /pubmed/32191754 http://dx.doi.org/10.1371/journal.pone.0230449 Text en © 2020 Gondhowiardjo et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Gondhowiardjo, Soehartati A.
Handoko,
Adham, Marlinda
Rachmadi, Lisnawati
Kodrat, Henry
Tobing, Demak Lumban
Haryoga, I. Made
Dwiyono, Agustinus Gatot
Kristian, Yoseph Adi
Mayang Permata, Tiara Bunga
Tumor microenvironment predicts local tumor extensiveness in PD-L1 positive nasopharyngeal cancer
title Tumor microenvironment predicts local tumor extensiveness in PD-L1 positive nasopharyngeal cancer
title_full Tumor microenvironment predicts local tumor extensiveness in PD-L1 positive nasopharyngeal cancer
title_fullStr Tumor microenvironment predicts local tumor extensiveness in PD-L1 positive nasopharyngeal cancer
title_full_unstemmed Tumor microenvironment predicts local tumor extensiveness in PD-L1 positive nasopharyngeal cancer
title_short Tumor microenvironment predicts local tumor extensiveness in PD-L1 positive nasopharyngeal cancer
title_sort tumor microenvironment predicts local tumor extensiveness in pd-l1 positive nasopharyngeal cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082005/
https://www.ncbi.nlm.nih.gov/pubmed/32191754
http://dx.doi.org/10.1371/journal.pone.0230449
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