Podocyte-specific deletion of tubular sclerosis complex 2 promotes focal segmental glomerulosclerosis and progressive renal failure

Obesity can initiate and accelerate the progression of kidney diseases. However, it remains unclear how obesity affects renal dysfunction. Here, we show that a newly generated podocyte-specific tubular sclerosis complex 2 (Tsc2) knockout mouse model (Tsc2(Δpodocyte)) develops proteinuria and dies du...

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Detalles Bibliográficos
Autores principales: Iwata, Wakiko, Unoki-Kubota, Hiroyuki, Kato, Hideki, Shimizu, Akira, Matsumoto, Michihiro, Imasawa, Toshiyuki, Igarashi, Arisa, Matsumoto, Kenji, Noda, Tetsuo, Terauchi, Yasuo, Nangaku, Masaomi, Kasuga, Masato, Kaburagi, Yasushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082048/
https://www.ncbi.nlm.nih.gov/pubmed/32191726
http://dx.doi.org/10.1371/journal.pone.0229397

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