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BRCA1 and S Phase DNA Repair Pathways Restrict LINE-1 Retrotransposition in Human Cells

Long interspersed element-1 (LINE-1 or L1) is the only autonomous retrotransposon active in human cells. Different host factors have been shown to influence L1 mobility however, systematic analyses of these factors are limited. Here, we developed a high-throughput microscopy-based retrotransposition...

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Detalles Bibliográficos
Autores principales:	Mita, Paolo, Sun, Xiaoji, Fenyö, David, Kahler, David J., Li, Donghui, Agmon, Neta, Wudzinska, Aleksandra, Keegan, Sarah, Bader, Joel S., Yun, Chi, Boeke, Jef D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082080/ https://www.ncbi.nlm.nih.gov/pubmed/32042152 http://dx.doi.org/10.1038/s41594-020-0374-z

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