Expanding Clinical Phenotype and Novel Insights into the Pathogenesis of ICOS Deficiency

BACKGROUND: Inducible T cell co-stimulator (ICOS) deficiency has been categorized as a combined immunodeficiency often complicated by enteropathies, autoimmunity, lymphoproliferation, and malignancy. We report seven new patients and four novel ICOS mutations resulting in a common variable immunodefi...

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Detalles Bibliográficos
Autores principales: Abolhassani, Hassan, El-Sherbiny, Yasser M., Arumugakani, Gururaj, Carter, Clive, Richards, Stephen, Lawless, Dylan, Wood, Philip, Buckland, Matthew, Heydarzadeh, Marzieh, Aghamohammadi, Asghar, Hambleton, Sophie, Hammarström, Lennart, Burns, Siobhan O, Doffinger, Rainer, Savic, Sinisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082411/
https://www.ncbi.nlm.nih.gov/pubmed/31858365
http://dx.doi.org/10.1007/s10875-019-00735-z

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