Impact of global PTP1B deficiency on the gut barrier permeability during NASH in mice

OBJECTIVE: Non-alcoholic steatohepatitis (NASH) is characterized by a robust pro-inflammatory component at both hepatic and systemic levels together with a disease-specific gut microbiome signature. Protein tyrosine phosphatase 1 B (PTP1B) plays distinct roles in non-immune and immune cells, in the...

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Detalles Bibliográficos
Autores principales: Rubio, Carmen, Puerto, Marta, García-Rodríquez, Juan J., Lu, Van B., García-Martínez, Irma, Alén, Rosa, Sanmartín-Salinas, Patricia, Toledo-Lobo, M. Val, Saiz, Jorge, Ruperez, Javier, Barbas, Coral, Menchén, Luis, Gribble, Fiona M., Reimann, Frank, Guijarro, Luis G., Carrascosa, Jose M., Valverde, Ángela M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082558/
https://www.ncbi.nlm.nih.gov/pubmed/32244182
http://dx.doi.org/10.1016/j.molmet.2020.01.018

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