Validation of a stability-indicating HPLC-UV method for the quantification of acetazolamide in Oral-Mix and Oral-Mix SF

This manuscript details the modifications made to the HPLC assay method described in the USP monograph for Acetazolamide Compounded Oral Suspension. • The method was modified to allow the quantification of acetazolamide in two new suspension vehicles: Oral Mix and Oral Mix SF; • It was validated for...

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Detalles Bibliográficos
Autores principales: Gillium, Charlotte, Friciu, Mihaela, Abatzoglou, Nicolas, Leclair, Grégoire
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Pharmacology, Toxicology and Pharmaceutical Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082594/
https://www.ncbi.nlm.nih.gov/pubmed/32211305
http://dx.doi.org/10.1016/j.mex.2020.100844
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author Gillium, Charlotte
Friciu, Mihaela
Abatzoglou, Nicolas
Leclair, Grégoire
author_facet Gillium, Charlotte
Friciu, Mihaela
Abatzoglou, Nicolas
Leclair, Grégoire
author_sort Gillium, Charlotte
collection PubMed
description This manuscript details the modifications made to the HPLC assay method described in the USP monograph for Acetazolamide Compounded Oral Suspension. • The method was modified to allow the quantification of acetazolamide in two new suspension vehicles: Oral Mix and Oral Mix SF; • It was validated for linearity, accuracy, precision and specificity; • It was demonstrated stability-indicating and suitable for use in a stability study using these vehicles.
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spelling pubmed-70825942020-03-24 Validation of a stability-indicating HPLC-UV method for the quantification of acetazolamide in Oral-Mix and Oral-Mix SF Gillium, Charlotte Friciu, Mihaela Abatzoglou, Nicolas Leclair, Grégoire MethodsX Pharmacology, Toxicology and Pharmaceutical Science This manuscript details the modifications made to the HPLC assay method described in the USP monograph for Acetazolamide Compounded Oral Suspension. • The method was modified to allow the quantification of acetazolamide in two new suspension vehicles: Oral Mix and Oral Mix SF; • It was validated for linearity, accuracy, precision and specificity; • It was demonstrated stability-indicating and suitable for use in a stability study using these vehicles. Elsevier 2020-02-27 /pmc/articles/PMC7082594/ /pubmed/32211305 http://dx.doi.org/10.1016/j.mex.2020.100844 Text en © 2020 The Authors. Published by Elsevier B.V. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Pharmacology, Toxicology and Pharmaceutical Science
Gillium, Charlotte
Friciu, Mihaela
Abatzoglou, Nicolas
Leclair, Grégoire
Validation of a stability-indicating HPLC-UV method for the quantification of acetazolamide in Oral-Mix and Oral-Mix SF
title Validation of a stability-indicating HPLC-UV method for the quantification of acetazolamide in Oral-Mix and Oral-Mix SF
title_full Validation of a stability-indicating HPLC-UV method for the quantification of acetazolamide in Oral-Mix and Oral-Mix SF
title_fullStr Validation of a stability-indicating HPLC-UV method for the quantification of acetazolamide in Oral-Mix and Oral-Mix SF
title_full_unstemmed Validation of a stability-indicating HPLC-UV method for the quantification of acetazolamide in Oral-Mix and Oral-Mix SF
title_short Validation of a stability-indicating HPLC-UV method for the quantification of acetazolamide in Oral-Mix and Oral-Mix SF
title_sort validation of a stability-indicating hplc-uv method for the quantification of acetazolamide in oral-mix and oral-mix sf
topic Pharmacology, Toxicology and Pharmaceutical Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082594/
https://www.ncbi.nlm.nih.gov/pubmed/32211305
http://dx.doi.org/10.1016/j.mex.2020.100844
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