Targeting P4HA1 with a Small Molecule Inhibitor in a Colorectal Cancer PDX Model()

Deposition, remodeling, and signaling of the extracellular matrix facilitate tumor growth and metastasis. Here, we demonstrated that an enzyme, collagen prolyl 4-hydroxylase, alpha polypeptide I (P4HA1), which is involved in collagen synthesis and deposition, had elevated expression in colorectal ca...

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Detalles Bibliográficos
Autores principales: Agarwal, Sumit, Behring, Michael, Kim, Hyung-Gyoon, Bajpai, Prachi, Chakravarthi, Balabhadrapatruni V.S.K., Gupta, Nirzari, Elkholy, Amr, Al Diffalha, Sameer, Varambally, Sooryanarayana, Manne, Upender
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2020
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082635/
https://www.ncbi.nlm.nih.gov/pubmed/32199274
http://dx.doi.org/10.1016/j.tranon.2020.100754

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082635/
https://www.ncbi.nlm.nih.gov/pubmed/32199274
http://dx.doi.org/10.1016/j.tranon.2020.100754

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