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Targeting P4HA1 with a Small Molecule Inhibitor in a Colorectal Cancer PDX Model()
Deposition, remodeling, and signaling of the extracellular matrix facilitate tumor growth and metastasis. Here, we demonstrated that an enzyme, collagen prolyl 4-hydroxylase, alpha polypeptide I (P4HA1), which is involved in collagen synthesis and deposition, had elevated expression in colorectal ca...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Neoplasia Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082635/ https://www.ncbi.nlm.nih.gov/pubmed/32199274 http://dx.doi.org/10.1016/j.tranon.2020.100754 |