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How I treat malignant pleural mesothelioma
Malignant pleural mesothelioma is a rare and aggressive malignancy mostly associated with occupational asbestos exposure. Prognosis is poor and only highly selected patients may benefit from aggressive surgical management, also as part of a multimodal approach. In advanced disease, the combination o...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082638/ https://www.ncbi.nlm.nih.gov/pubmed/32156681 http://dx.doi.org/10.1136/esmoopen-2019-000669 |
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author | Viscardi, Giuseppe Di Liello, Raimondo Morgillo, Floriana |
author_facet | Viscardi, Giuseppe Di Liello, Raimondo Morgillo, Floriana |
author_sort | Viscardi, Giuseppe |
collection | PubMed |
description | Malignant pleural mesothelioma is a rare and aggressive malignancy mostly associated with occupational asbestos exposure. Prognosis is poor and only highly selected patients may benefit from aggressive surgical management, also as part of a multimodal approach. In advanced disease, the combination of pemetrexed and platinum remains the only established treatment, while efficacy evidence of second line chemotherapy is lacking. Thus, a deeper knowledge of biology of the disease and more effective treatments are urgently needed. Refer to specialised centres with multidisciplinary expertise is mandatory, as well as inclusion of patients in clinical trials is advisable whenever possible. In all stages of disease focus on symptoms control is paramount. |
format | Online Article Text |
id | pubmed-7082638 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-70826382020-03-23 How I treat malignant pleural mesothelioma Viscardi, Giuseppe Di Liello, Raimondo Morgillo, Floriana ESMO Open Review Malignant pleural mesothelioma is a rare and aggressive malignancy mostly associated with occupational asbestos exposure. Prognosis is poor and only highly selected patients may benefit from aggressive surgical management, also as part of a multimodal approach. In advanced disease, the combination of pemetrexed and platinum remains the only established treatment, while efficacy evidence of second line chemotherapy is lacking. Thus, a deeper knowledge of biology of the disease and more effective treatments are urgently needed. Refer to specialised centres with multidisciplinary expertise is mandatory, as well as inclusion of patients in clinical trials is advisable whenever possible. In all stages of disease focus on symptoms control is paramount. BMJ Publishing Group 2020-03-10 /pmc/articles/PMC7082638/ /pubmed/32156681 http://dx.doi.org/10.1136/esmoopen-2019-000669 Text en © Author (s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ on behalf of the European Society for Medical Oncology. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and any changes made are indicated. See: https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Review Viscardi, Giuseppe Di Liello, Raimondo Morgillo, Floriana How I treat malignant pleural mesothelioma |
title | How I treat malignant pleural mesothelioma |
title_full | How I treat malignant pleural mesothelioma |
title_fullStr | How I treat malignant pleural mesothelioma |
title_full_unstemmed | How I treat malignant pleural mesothelioma |
title_short | How I treat malignant pleural mesothelioma |
title_sort | how i treat malignant pleural mesothelioma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082638/ https://www.ncbi.nlm.nih.gov/pubmed/32156681 http://dx.doi.org/10.1136/esmoopen-2019-000669 |
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