The Apelin/APJ System in Psychosis and Neuropathy

Apelin, an endogenous neuropeptide, has been identified as the cognate ligand for the G-protein-coupled receptor APJ. Apelin, APJ messenger RNA, and protein are widely expressed in the central nervous system and peripheral tissues of humans and animals. The apelin/APJ system has been implicated in d...

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Autores principales: Lv, Shuang-Yu, Chen, Wei-Dong, Wang, Yan-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082832/
https://www.ncbi.nlm.nih.gov/pubmed/32231577
http://dx.doi.org/10.3389/fphar.2020.00320
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author Lv, Shuang-Yu
Chen, Wei-Dong
Wang, Yan-Dong
author_facet Lv, Shuang-Yu
Chen, Wei-Dong
Wang, Yan-Dong
author_sort Lv, Shuang-Yu
collection PubMed
description Apelin, an endogenous neuropeptide, has been identified as the cognate ligand for the G-protein-coupled receptor APJ. Apelin, APJ messenger RNA, and protein are widely expressed in the central nervous system and peripheral tissues of humans and animals. The apelin/APJ system has been implicated in diverse physiological and pathological processes. The present article reviews the progress of the latest research investigating the apelin/APJ system in pain, depression, anxiety, memory, epilepsy, neuroprotection, stroke, and brain injury and protection, and highlights its promising potential as a therapeutic target for treatment of psychosis and neuropathy.
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spelling pubmed-70828322020-03-30 The Apelin/APJ System in Psychosis and Neuropathy Lv, Shuang-Yu Chen, Wei-Dong Wang, Yan-Dong Front Pharmacol Pharmacology Apelin, an endogenous neuropeptide, has been identified as the cognate ligand for the G-protein-coupled receptor APJ. Apelin, APJ messenger RNA, and protein are widely expressed in the central nervous system and peripheral tissues of humans and animals. The apelin/APJ system has been implicated in diverse physiological and pathological processes. The present article reviews the progress of the latest research investigating the apelin/APJ system in pain, depression, anxiety, memory, epilepsy, neuroprotection, stroke, and brain injury and protection, and highlights its promising potential as a therapeutic target for treatment of psychosis and neuropathy. Frontiers Media S.A. 2020-03-13 /pmc/articles/PMC7082832/ /pubmed/32231577 http://dx.doi.org/10.3389/fphar.2020.00320 Text en Copyright © 2020 Lv, Chen and Wang http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Lv, Shuang-Yu
Chen, Wei-Dong
Wang, Yan-Dong
The Apelin/APJ System in Psychosis and Neuropathy
title The Apelin/APJ System in Psychosis and Neuropathy
title_full The Apelin/APJ System in Psychosis and Neuropathy
title_fullStr The Apelin/APJ System in Psychosis and Neuropathy
title_full_unstemmed The Apelin/APJ System in Psychosis and Neuropathy
title_short The Apelin/APJ System in Psychosis and Neuropathy
title_sort apelin/apj system in psychosis and neuropathy
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082832/
https://www.ncbi.nlm.nih.gov/pubmed/32231577
http://dx.doi.org/10.3389/fphar.2020.00320
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