Cargando…

Neck lymph node metastasis detection in patients with differentiated thyroid carcinoma (DTC) in long-term follow-up: a (131)I-SPECT/CT study

BACKGROUND: The identification of neck lymph node (LN) metastases represents a very important issue in the management of patients with differentiated thyroid carcinoma (DTC). To this purpose, in the present study, we used 131I-SPECT/CT as a diagnostic imaging procedure. METHODS: A consecutive series...

Descripción completa

Detalles Bibliográficos
Autores principales: Spanu, Angela, Nuvoli, Susanna, Marongiu, Andrea, Gelo, Ilaria, Mele, Luciana, Piras, Bastiana, Madeddu, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083046/
https://www.ncbi.nlm.nih.gov/pubmed/32197595
http://dx.doi.org/10.1186/s12885-020-06744-1
_version_ 1783508464827367424
author Spanu, Angela
Nuvoli, Susanna
Marongiu, Andrea
Gelo, Ilaria
Mele, Luciana
Piras, Bastiana
Madeddu, Giuseppe
author_facet Spanu, Angela
Nuvoli, Susanna
Marongiu, Andrea
Gelo, Ilaria
Mele, Luciana
Piras, Bastiana
Madeddu, Giuseppe
author_sort Spanu, Angela
collection PubMed
description BACKGROUND: The identification of neck lymph node (LN) metastases represents a very important issue in the management of patients with differentiated thyroid carcinoma (DTC). To this purpose, in the present study, we used 131I-SPECT/CT as a diagnostic imaging procedure. METHODS: A consecutive series of 224 DTC patients with ascertained neck radioiodine-avid foci at (131)I-SPECT/CT during long-term follow-up was evaluated. All patients had already undergone total thyroidectomy and radioiodine therapy and had been classified as follows: 62 at high risk (H), 64 at low risk (L) and 98 at very low risk (VL). (131)I-Whole body scan (WBS) followed by SPECT/CT was performed in all cases. RESULTS: In the 224 patients, 449 neck iodine avid foci were ascertained at SPECT/CT, while 322 were evidenced at WBS in 165/224 patients. WBS classified as residues 263/322 foci and as unclear 59/322 foci; among the former foci SPECT/CT correctly characterized 8 LN metastases and 3 physiologic uptakes and among the latter, it pinpointed 26 LN metastases, 18 residues, and 15 physiologic uptakes. SPECT/CT also classified 127 foci occult at WBS as 59 LN metastases and 68 residues. Globally, SPECT/CT identified 93 LN metastases in 59 patients (26 H, 20 L, 13 VL), while WBS evidenced 34 in 25 cases. All 13 VL patients, T1aN0M0, 5 of whom with LN near sub-mandibular glands, had thyroglobulin undetectable or < 2.5 ng/ml. Globally, SPECT/CT obtained an incremental value than WBS in 45.5% of patients, a more correct patient classification changing therapeutic approach in 30.3% of cases and identified WBS false-positive findings in 8% of cases. CONCLUSIONS: (131)I-SPECT/CT proved to correctly detect and characterize neck LN metastases in DTC patients in long-term follow-up, improving the performance of planar WBS. SPECT/CT routine use is thus suggested; its role is particularly relevant in patients with WBS inconclusive, VL, T1aN0M0 and with undetectable or very low thyroglobulin levels.
format Online
Article
Text
id pubmed-7083046
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-70830462020-03-23 Neck lymph node metastasis detection in patients with differentiated thyroid carcinoma (DTC) in long-term follow-up: a (131)I-SPECT/CT study Spanu, Angela Nuvoli, Susanna Marongiu, Andrea Gelo, Ilaria Mele, Luciana Piras, Bastiana Madeddu, Giuseppe BMC Cancer Research Article BACKGROUND: The identification of neck lymph node (LN) metastases represents a very important issue in the management of patients with differentiated thyroid carcinoma (DTC). To this purpose, in the present study, we used 131I-SPECT/CT as a diagnostic imaging procedure. METHODS: A consecutive series of 224 DTC patients with ascertained neck radioiodine-avid foci at (131)I-SPECT/CT during long-term follow-up was evaluated. All patients had already undergone total thyroidectomy and radioiodine therapy and had been classified as follows: 62 at high risk (H), 64 at low risk (L) and 98 at very low risk (VL). (131)I-Whole body scan (WBS) followed by SPECT/CT was performed in all cases. RESULTS: In the 224 patients, 449 neck iodine avid foci were ascertained at SPECT/CT, while 322 were evidenced at WBS in 165/224 patients. WBS classified as residues 263/322 foci and as unclear 59/322 foci; among the former foci SPECT/CT correctly characterized 8 LN metastases and 3 physiologic uptakes and among the latter, it pinpointed 26 LN metastases, 18 residues, and 15 physiologic uptakes. SPECT/CT also classified 127 foci occult at WBS as 59 LN metastases and 68 residues. Globally, SPECT/CT identified 93 LN metastases in 59 patients (26 H, 20 L, 13 VL), while WBS evidenced 34 in 25 cases. All 13 VL patients, T1aN0M0, 5 of whom with LN near sub-mandibular glands, had thyroglobulin undetectable or < 2.5 ng/ml. Globally, SPECT/CT obtained an incremental value than WBS in 45.5% of patients, a more correct patient classification changing therapeutic approach in 30.3% of cases and identified WBS false-positive findings in 8% of cases. CONCLUSIONS: (131)I-SPECT/CT proved to correctly detect and characterize neck LN metastases in DTC patients in long-term follow-up, improving the performance of planar WBS. SPECT/CT routine use is thus suggested; its role is particularly relevant in patients with WBS inconclusive, VL, T1aN0M0 and with undetectable or very low thyroglobulin levels. BioMed Central 2020-03-20 /pmc/articles/PMC7083046/ /pubmed/32197595 http://dx.doi.org/10.1186/s12885-020-06744-1 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Spanu, Angela
Nuvoli, Susanna
Marongiu, Andrea
Gelo, Ilaria
Mele, Luciana
Piras, Bastiana
Madeddu, Giuseppe
Neck lymph node metastasis detection in patients with differentiated thyroid carcinoma (DTC) in long-term follow-up: a (131)I-SPECT/CT study
title Neck lymph node metastasis detection in patients with differentiated thyroid carcinoma (DTC) in long-term follow-up: a (131)I-SPECT/CT study
title_full Neck lymph node metastasis detection in patients with differentiated thyroid carcinoma (DTC) in long-term follow-up: a (131)I-SPECT/CT study
title_fullStr Neck lymph node metastasis detection in patients with differentiated thyroid carcinoma (DTC) in long-term follow-up: a (131)I-SPECT/CT study
title_full_unstemmed Neck lymph node metastasis detection in patients with differentiated thyroid carcinoma (DTC) in long-term follow-up: a (131)I-SPECT/CT study
title_short Neck lymph node metastasis detection in patients with differentiated thyroid carcinoma (DTC) in long-term follow-up: a (131)I-SPECT/CT study
title_sort neck lymph node metastasis detection in patients with differentiated thyroid carcinoma (dtc) in long-term follow-up: a (131)i-spect/ct study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083046/
https://www.ncbi.nlm.nih.gov/pubmed/32197595
http://dx.doi.org/10.1186/s12885-020-06744-1
work_keys_str_mv AT spanuangela necklymphnodemetastasisdetectioninpatientswithdifferentiatedthyroidcarcinomadtcinlongtermfollowupa131ispectctstudy
AT nuvolisusanna necklymphnodemetastasisdetectioninpatientswithdifferentiatedthyroidcarcinomadtcinlongtermfollowupa131ispectctstudy
AT marongiuandrea necklymphnodemetastasisdetectioninpatientswithdifferentiatedthyroidcarcinomadtcinlongtermfollowupa131ispectctstudy
AT geloilaria necklymphnodemetastasisdetectioninpatientswithdifferentiatedthyroidcarcinomadtcinlongtermfollowupa131ispectctstudy
AT meleluciana necklymphnodemetastasisdetectioninpatientswithdifferentiatedthyroidcarcinomadtcinlongtermfollowupa131ispectctstudy
AT pirasbastiana necklymphnodemetastasisdetectioninpatientswithdifferentiatedthyroidcarcinomadtcinlongtermfollowupa131ispectctstudy
AT madeddugiuseppe necklymphnodemetastasisdetectioninpatientswithdifferentiatedthyroidcarcinomadtcinlongtermfollowupa131ispectctstudy