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Sirt6 opposes glycochenodeoxycholate-induced apoptosis of biliary epithelial cells through the AMPK/PGC-1α pathway

BACKGROUND: Induction of biliary epithelial cell apoptosis by toxic bile acids is involved in the development of cholestatic disease, but the underlying molecular mechanism is not clear. The purpose of this study was to investigate the molecular mechanisms involved in Sirt6 protection against the ap...

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Detalles Bibliográficos
Autores principales:	Li, Jiye, Yu, Dongsheng, Chen, Sanyang, Liu, Yifan, Shi, Jihua, Zhang, Jiakai, Wen, Peihao, Wang, Zhihui, Li, Jie, Guo, Wenzhi, Zhang, Shuijun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083051/ https://www.ncbi.nlm.nih.gov/pubmed/32206298 http://dx.doi.org/10.1186/s13578-020-00402-6

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