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Moderate to severe acute pain disturbs motor cortex intracortical inhibition and facilitation in orthopedic trauma patients: A TMS study

OBJECTIVE: Primary motor (M1) cortical excitability alterations are involved in the development and maintenance of chronic pain. Less is known about M1-cortical excitability implications in the acute phase of an orthopedic trauma. This study aims to assess acute M1-cortical excitability in patients...

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Autores principales: Jodoin, Marianne, Rouleau, Dominique M., Bellemare, Audrey, Provost, Catherine, Larson-Dupuis, Camille, Sandman, Émilie, Laflamme, Georges-Yves, Benoit, Benoit, Leduc, Stéphane, Levesque, Martine, Gosselin, Nadia, De Beaumont, Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083311/
https://www.ncbi.nlm.nih.gov/pubmed/32196498
http://dx.doi.org/10.1371/journal.pone.0226452
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author Jodoin, Marianne
Rouleau, Dominique M.
Bellemare, Audrey
Provost, Catherine
Larson-Dupuis, Camille
Sandman, Émilie
Laflamme, Georges-Yves
Benoit, Benoit
Leduc, Stéphane
Levesque, Martine
Gosselin, Nadia
De Beaumont, Louis
author_facet Jodoin, Marianne
Rouleau, Dominique M.
Bellemare, Audrey
Provost, Catherine
Larson-Dupuis, Camille
Sandman, Émilie
Laflamme, Georges-Yves
Benoit, Benoit
Leduc, Stéphane
Levesque, Martine
Gosselin, Nadia
De Beaumont, Louis
author_sort Jodoin, Marianne
collection PubMed
description OBJECTIVE: Primary motor (M1) cortical excitability alterations are involved in the development and maintenance of chronic pain. Less is known about M1-cortical excitability implications in the acute phase of an orthopedic trauma. This study aims to assess acute M1-cortical excitability in patients with an isolated upper limb fracture (IULF) in relation to pain intensity. METHODS: Eighty-four (56 IULF patients <14 days post-trauma and 28 healthy controls). IULF patients were divided into two subgroups according to pain intensity (mild versus moderate to severe pain). A single transcranial magnetic stimulation (TMS) session was performed over M1 to compare groups on resting motor threshold (rMT), short-intracortical inhibition (SICI), intracortical facilitation (ICF), and long-interval cortical inhibition (LICI). RESULTS: Reduced SICI and ICF were found in IULF patients with moderate to severe pain, whereas mild pain was not associated with M1 alterations. Age, sex, and time since the accident had no influence on TMS measures. DISCUSSION: These findings show altered M1 in the context of acute moderate to severe pain, suggesting early signs of altered GABAergic inhibitory and glutamatergic facilitatory activities.
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spelling pubmed-70833112020-03-24 Moderate to severe acute pain disturbs motor cortex intracortical inhibition and facilitation in orthopedic trauma patients: A TMS study Jodoin, Marianne Rouleau, Dominique M. Bellemare, Audrey Provost, Catherine Larson-Dupuis, Camille Sandman, Émilie Laflamme, Georges-Yves Benoit, Benoit Leduc, Stéphane Levesque, Martine Gosselin, Nadia De Beaumont, Louis PLoS One Research Article OBJECTIVE: Primary motor (M1) cortical excitability alterations are involved in the development and maintenance of chronic pain. Less is known about M1-cortical excitability implications in the acute phase of an orthopedic trauma. This study aims to assess acute M1-cortical excitability in patients with an isolated upper limb fracture (IULF) in relation to pain intensity. METHODS: Eighty-four (56 IULF patients <14 days post-trauma and 28 healthy controls). IULF patients were divided into two subgroups according to pain intensity (mild versus moderate to severe pain). A single transcranial magnetic stimulation (TMS) session was performed over M1 to compare groups on resting motor threshold (rMT), short-intracortical inhibition (SICI), intracortical facilitation (ICF), and long-interval cortical inhibition (LICI). RESULTS: Reduced SICI and ICF were found in IULF patients with moderate to severe pain, whereas mild pain was not associated with M1 alterations. Age, sex, and time since the accident had no influence on TMS measures. DISCUSSION: These findings show altered M1 in the context of acute moderate to severe pain, suggesting early signs of altered GABAergic inhibitory and glutamatergic facilitatory activities. Public Library of Science 2020-03-20 /pmc/articles/PMC7083311/ /pubmed/32196498 http://dx.doi.org/10.1371/journal.pone.0226452 Text en © 2020 Jodoin et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Jodoin, Marianne
Rouleau, Dominique M.
Bellemare, Audrey
Provost, Catherine
Larson-Dupuis, Camille
Sandman, Émilie
Laflamme, Georges-Yves
Benoit, Benoit
Leduc, Stéphane
Levesque, Martine
Gosselin, Nadia
De Beaumont, Louis
Moderate to severe acute pain disturbs motor cortex intracortical inhibition and facilitation in orthopedic trauma patients: A TMS study
title Moderate to severe acute pain disturbs motor cortex intracortical inhibition and facilitation in orthopedic trauma patients: A TMS study
title_full Moderate to severe acute pain disturbs motor cortex intracortical inhibition and facilitation in orthopedic trauma patients: A TMS study
title_fullStr Moderate to severe acute pain disturbs motor cortex intracortical inhibition and facilitation in orthopedic trauma patients: A TMS study
title_full_unstemmed Moderate to severe acute pain disturbs motor cortex intracortical inhibition and facilitation in orthopedic trauma patients: A TMS study
title_short Moderate to severe acute pain disturbs motor cortex intracortical inhibition and facilitation in orthopedic trauma patients: A TMS study
title_sort moderate to severe acute pain disturbs motor cortex intracortical inhibition and facilitation in orthopedic trauma patients: a tms study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083311/
https://www.ncbi.nlm.nih.gov/pubmed/32196498
http://dx.doi.org/10.1371/journal.pone.0226452
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