In vitro characterization of virulence factors among species of the Candida parapsilosis complex

INTRODUCTION: Candida parapsilosis complex species differ from each other with regard to their prevalence and virulence. METHODS: The hydrolytic enzyme activity, biofilm production, and adhesion to epithelial cells were analyzed in 87 C. parapsilosis complex strains. RESULTS: Among the studied isola...

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Detalles Bibliográficos
Autores principales: Ataides, Fábio Silvestre, Costa, Carolina Rodrigues, Santos, Andressa Santana, Freitas, Vivianny Aparecida Queiroz, Silva, Thaisa Cristina, Zara, Ana Laura Sene Amâncio, Jesuino, Rosália Santos Amorim, Silva, Maria Rosário Rodrigues
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Medicina Tropical - SBMT 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083369/
https://www.ncbi.nlm.nih.gov/pubmed/31994664
http://dx.doi.org/10.1590/0037-8682-0336-2019
Descripción
Sumario:INTRODUCTION: Candida parapsilosis complex species differ from each other with regard to their prevalence and virulence. METHODS: The hydrolytic enzyme activity, biofilm production, and adhesion to epithelial cells were analyzed in 87 C. parapsilosis complex strains. RESULTS: Among the studied isolates, 97.7%, 63.2%, and 82.8% exhibited very strong proteinase, esterase, and hemolysin activity, respectively. All the C. parapsilosis complex isolates produced biofilms and presented an average adherence of 96.0 yeasts/100 epithelial cells. CONCLUSIONS: Our results show that Candida parapsilosis complex isolates showed different levels of enzyme activity, biofilm production, and adhesion to epithelial cells.

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