Investigation of carbapenemases and aminoglycoside modifying enzymes of Acinetobacter baumannii isolates recovered from patients admitted to intensive care units in a tertiary-care hospital in Brazil

INTRODUCTION: Acinetobacter baumannii are opportunistic bacteria, highly capable of acquiring antimicrobial resistance through the production of carbapenemases and aminoglycoside modifying enzymes (AMEs). METHODS: Carbapenemase and AME genes were investigated in A. baumannii recovered from inpatient...

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Detalles Bibliográficos
Autores principales: Polotto, Milena, Casella, Tiago, Tolentino, Fernanda Modesto, Mataruco, Mayra Mioto, Porto, Naiady Konno Madela, Binhardi, Mirella Fontana Batista, Nogueira, Mara Corrêa Lelles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Medicina Tropical - SBMT 2019
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083385/
https://www.ncbi.nlm.nih.gov/pubmed/31859941
http://dx.doi.org/10.1590/0037-8682-0094-2019
Descripción
Sumario:INTRODUCTION: Acinetobacter baumannii are opportunistic bacteria, highly capable of acquiring antimicrobial resistance through the production of carbapenemases and aminoglycoside modifying enzymes (AMEs). METHODS: Carbapenemase and AME genes were investigated in A. baumannii recovered from inpatients of a Brazilian hospital. RESULTS: The key genes found were bla (OXA-51-like,) the association ISAba1- bla (OXA-23-like), and the AME genes aph(3´)-VI, aac(6´)-Ib, aac(3)-Ia, and aph(3´)-Ia. Different clusters spread through the institution wards. CONCLUSIONS: The dissemination of bla (OXA-23-like) and AME-carrying A. baumannii through the hospital highlights the need for improved preventive measures to reduce the spread of infection.

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