Investigation of carbapenemases and aminoglycoside modifying enzymes of Acinetobacter baumannii isolates recovered from patients admitted to intensive care units in a tertiary-care hospital in Brazil

INTRODUCTION: Acinetobacter baumannii are opportunistic bacteria, highly capable of acquiring antimicrobial resistance through the production of carbapenemases and aminoglycoside modifying enzymes (AMEs). METHODS: Carbapenemase and AME genes were investigated in A. baumannii recovered from inpatient...

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Autores principales: Polotto, Milena, Casella, Tiago, Tolentino, Fernanda Modesto, Mataruco, Mayra Mioto, Porto, Naiady Konno Madela, Binhardi, Mirella Fontana Batista, Nogueira, Mara Corrêa Lelles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Medicina Tropical - SBMT 2019
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083385/
https://www.ncbi.nlm.nih.gov/pubmed/31859941
http://dx.doi.org/10.1590/0037-8682-0094-2019
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author Polotto, Milena
Casella, Tiago
Tolentino, Fernanda Modesto
Mataruco, Mayra Mioto
Porto, Naiady Konno Madela
Binhardi, Mirella Fontana Batista
Nogueira, Mara Corrêa Lelles
author_facet Polotto, Milena
Casella, Tiago
Tolentino, Fernanda Modesto
Mataruco, Mayra Mioto
Porto, Naiady Konno Madela
Binhardi, Mirella Fontana Batista
Nogueira, Mara Corrêa Lelles
author_sort Polotto, Milena
collection PubMed
description INTRODUCTION: Acinetobacter baumannii are opportunistic bacteria, highly capable of acquiring antimicrobial resistance through the production of carbapenemases and aminoglycoside modifying enzymes (AMEs). METHODS: Carbapenemase and AME genes were investigated in A. baumannii recovered from inpatients of a Brazilian hospital. RESULTS: The key genes found were bla (OXA-51-like,) the association ISAba1- bla (OXA-23-like), and the AME genes aph(3´)-VI, aac(6´)-Ib, aac(3)-Ia, and aph(3´)-Ia. Different clusters spread through the institution wards. CONCLUSIONS: The dissemination of bla (OXA-23-like) and AME-carrying A. baumannii through the hospital highlights the need for improved preventive measures to reduce the spread of infection.
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spelling pubmed-70833852020-03-25 Investigation of carbapenemases and aminoglycoside modifying enzymes of Acinetobacter baumannii isolates recovered from patients admitted to intensive care units in a tertiary-care hospital in Brazil Polotto, Milena Casella, Tiago Tolentino, Fernanda Modesto Mataruco, Mayra Mioto Porto, Naiady Konno Madela Binhardi, Mirella Fontana Batista Nogueira, Mara Corrêa Lelles Rev Soc Bras Med Trop Short Communication INTRODUCTION: Acinetobacter baumannii are opportunistic bacteria, highly capable of acquiring antimicrobial resistance through the production of carbapenemases and aminoglycoside modifying enzymes (AMEs). METHODS: Carbapenemase and AME genes were investigated in A. baumannii recovered from inpatients of a Brazilian hospital. RESULTS: The key genes found were bla (OXA-51-like,) the association ISAba1- bla (OXA-23-like), and the AME genes aph(3´)-VI, aac(6´)-Ib, aac(3)-Ia, and aph(3´)-Ia. Different clusters spread through the institution wards. CONCLUSIONS: The dissemination of bla (OXA-23-like) and AME-carrying A. baumannii through the hospital highlights the need for improved preventive measures to reduce the spread of infection. Sociedade Brasileira de Medicina Tropical - SBMT 2019-12-20 /pmc/articles/PMC7083385/ /pubmed/31859941 http://dx.doi.org/10.1590/0037-8682-0094-2019 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Short Communication
Polotto, Milena
Casella, Tiago
Tolentino, Fernanda Modesto
Mataruco, Mayra Mioto
Porto, Naiady Konno Madela
Binhardi, Mirella Fontana Batista
Nogueira, Mara Corrêa Lelles
Investigation of carbapenemases and aminoglycoside modifying enzymes of Acinetobacter baumannii isolates recovered from patients admitted to intensive care units in a tertiary-care hospital in Brazil
title Investigation of carbapenemases and aminoglycoside modifying enzymes of Acinetobacter baumannii isolates recovered from patients admitted to intensive care units in a tertiary-care hospital in Brazil
title_full Investigation of carbapenemases and aminoglycoside modifying enzymes of Acinetobacter baumannii isolates recovered from patients admitted to intensive care units in a tertiary-care hospital in Brazil
title_fullStr Investigation of carbapenemases and aminoglycoside modifying enzymes of Acinetobacter baumannii isolates recovered from patients admitted to intensive care units in a tertiary-care hospital in Brazil
title_full_unstemmed Investigation of carbapenemases and aminoglycoside modifying enzymes of Acinetobacter baumannii isolates recovered from patients admitted to intensive care units in a tertiary-care hospital in Brazil
title_short Investigation of carbapenemases and aminoglycoside modifying enzymes of Acinetobacter baumannii isolates recovered from patients admitted to intensive care units in a tertiary-care hospital in Brazil
title_sort investigation of carbapenemases and aminoglycoside modifying enzymes of acinetobacter baumannii isolates recovered from patients admitted to intensive care units in a tertiary-care hospital in brazil
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083385/
https://www.ncbi.nlm.nih.gov/pubmed/31859941
http://dx.doi.org/10.1590/0037-8682-0094-2019
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