Characterization of adverse reactions to benznidazole in patients with Chagas disease in the Federal District, Brazil

INTRODUCTION: Benznidazole is used for treating Chagas disease (CD). This cross-sectional study aimed to characterize the adverse drug reactions (ADRs) of benznidazole at a public hospital in Brazil’s Federal District. METHODS: Medical records were analyzed and ADRs were categorized by type, intensi...

Descripción completa

Detalles Bibliográficos
Autores principales: Gontijo, Maria Katarine Costa Lucas, de Arruda, Hilda Maria Benevides da Silva, Noronha, Elza Ferreira, de Toledo, Maria Inês
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Medicina Tropical - SBMT 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083386/
https://www.ncbi.nlm.nih.gov/pubmed/31994658
http://dx.doi.org/10.1590/0037-8682-0150-2019
_version_ 1783508522642702336
author Gontijo, Maria Katarine Costa Lucas
de Arruda, Hilda Maria Benevides da Silva
Noronha, Elza Ferreira
de Toledo, Maria Inês
author_facet Gontijo, Maria Katarine Costa Lucas
de Arruda, Hilda Maria Benevides da Silva
Noronha, Elza Ferreira
de Toledo, Maria Inês
author_sort Gontijo, Maria Katarine Costa Lucas
collection PubMed
description INTRODUCTION: Benznidazole is used for treating Chagas disease (CD). This cross-sectional study aimed to characterize the adverse drug reactions (ADRs) of benznidazole at a public hospital in Brazil’s Federal District. METHODS: Medical records were analyzed and ADRs were categorized by type, intensity, seriousness, and causality. RESULTS: Of the 62 patients who started benznidazole treatment for CD, 41 (66%) presented with 105 ADRs; 23 (37%) discontinued the treatment. Most reactions were classified as probable (81%), severe (63%), serious (67%), and dose-dependent (56%). CONCLUSIONS: The high incidence of ADRs because of treatment withdrawal revealed the need for safer alternatives for CD treatment.
format Online
Article
Text
id pubmed-7083386
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Sociedade Brasileira de Medicina Tropical - SBMT
record_format MEDLINE/PubMed
spelling pubmed-70833862020-03-25 Characterization of adverse reactions to benznidazole in patients with Chagas disease in the Federal District, Brazil Gontijo, Maria Katarine Costa Lucas de Arruda, Hilda Maria Benevides da Silva Noronha, Elza Ferreira de Toledo, Maria Inês Rev Soc Bras Med Trop Short Communication INTRODUCTION: Benznidazole is used for treating Chagas disease (CD). This cross-sectional study aimed to characterize the adverse drug reactions (ADRs) of benznidazole at a public hospital in Brazil’s Federal District. METHODS: Medical records were analyzed and ADRs were categorized by type, intensity, seriousness, and causality. RESULTS: Of the 62 patients who started benznidazole treatment for CD, 41 (66%) presented with 105 ADRs; 23 (37%) discontinued the treatment. Most reactions were classified as probable (81%), severe (63%), serious (67%), and dose-dependent (56%). CONCLUSIONS: The high incidence of ADRs because of treatment withdrawal revealed the need for safer alternatives for CD treatment. Sociedade Brasileira de Medicina Tropical - SBMT 2020-01-27 /pmc/articles/PMC7083386/ /pubmed/31994658 http://dx.doi.org/10.1590/0037-8682-0150-2019 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Short Communication
Gontijo, Maria Katarine Costa Lucas
de Arruda, Hilda Maria Benevides da Silva
Noronha, Elza Ferreira
de Toledo, Maria Inês
Characterization of adverse reactions to benznidazole in patients with Chagas disease in the Federal District, Brazil
title Characterization of adverse reactions to benznidazole in patients with Chagas disease in the Federal District, Brazil
title_full Characterization of adverse reactions to benznidazole in patients with Chagas disease in the Federal District, Brazil
title_fullStr Characterization of adverse reactions to benznidazole in patients with Chagas disease in the Federal District, Brazil
title_full_unstemmed Characterization of adverse reactions to benznidazole in patients with Chagas disease in the Federal District, Brazil
title_short Characterization of adverse reactions to benznidazole in patients with Chagas disease in the Federal District, Brazil
title_sort characterization of adverse reactions to benznidazole in patients with chagas disease in the federal district, brazil
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083386/
https://www.ncbi.nlm.nih.gov/pubmed/31994658
http://dx.doi.org/10.1590/0037-8682-0150-2019
work_keys_str_mv AT gontijomariakatarinecostalucas characterizationofadversereactionstobenznidazoleinpatientswithchagasdiseaseinthefederaldistrictbrazil
AT dearrudahildamariabenevidesdasilva characterizationofadversereactionstobenznidazoleinpatientswithchagasdiseaseinthefederaldistrictbrazil
AT noronhaelzaferreira characterizationofadversereactionstobenznidazoleinpatientswithchagasdiseaseinthefederaldistrictbrazil
AT detoledomariaines characterizationofadversereactionstobenznidazoleinpatientswithchagasdiseaseinthefederaldistrictbrazil

Ejemplares similares