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Study on amniotic fluid metabolism in the second trimester of Trisomy 21
BACKGROUND: Trisomy 21 is a common aneuploid condition in humans and accounts for approximately one quarter of all aneuploid live births. To date, early diagnosis of Trisomy 21 remains a challenging task. Metabolomics may prove an innovative tool to study the early pathophysiology of Trisomy 21 at a...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083445/ https://www.ncbi.nlm.nih.gov/pubmed/31709651 http://dx.doi.org/10.1002/jcla.23089 |
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author | Liu, Xiaoting Quan, Sheng Fu, Yurong Wang, Weiwei Zhang, Wenling Wang, Xiaofei Zhang, Chenxi Xiang, Daijun Zhang, Liwen Wang, Chengbin |
author_facet | Liu, Xiaoting Quan, Sheng Fu, Yurong Wang, Weiwei Zhang, Wenling Wang, Xiaofei Zhang, Chenxi Xiang, Daijun Zhang, Liwen Wang, Chengbin |
author_sort | Liu, Xiaoting |
collection | PubMed |
description | BACKGROUND: Trisomy 21 is a common aneuploid condition in humans and accounts for approximately one quarter of all aneuploid live births. To date, early diagnosis of Trisomy 21 remains a challenging task. Metabolomics may prove an innovative tool to study the early pathophysiology of Trisomy 21 at a functional level. METHODS: Ultra‐performance liquid chromatography coupled with mass spectrometer (UPLC‐MS) was used for untargeted metabolomic analysis of amniotic fluid samples from women having normal and trisomy 21 fetuses. RESULTS: Many significantly changed metabolites were identified between amniotic fluid samples from Trisomy 21 pregnancies and normal euploid pregnancies, such as generally lower levels of several steroid hormones and their derivatives, higher levels of glutathione catabolites coupled with lower levels of gamma‐glutamyl amino acids, and increased levels of phospholipid catabolites, sugars, and dicarboxylic acids. The identification of a human milk oligosaccharide in amniotic fluid may worth further investigation, since confirmation of this observation may have significant implications for regulation of fetal development. CONCLUSIONS: The metabolisms in amniotic fluid from Trisomy 21 and normal pregnancies are quite different, and some of the significantly changed metabolites may be considered as candidates of early diagnostic biomarkers for Trisomy 21. |
format | Online Article Text |
id | pubmed-7083445 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70834452020-03-24 Study on amniotic fluid metabolism in the second trimester of Trisomy 21 Liu, Xiaoting Quan, Sheng Fu, Yurong Wang, Weiwei Zhang, Wenling Wang, Xiaofei Zhang, Chenxi Xiang, Daijun Zhang, Liwen Wang, Chengbin J Clin Lab Anal Research Articles BACKGROUND: Trisomy 21 is a common aneuploid condition in humans and accounts for approximately one quarter of all aneuploid live births. To date, early diagnosis of Trisomy 21 remains a challenging task. Metabolomics may prove an innovative tool to study the early pathophysiology of Trisomy 21 at a functional level. METHODS: Ultra‐performance liquid chromatography coupled with mass spectrometer (UPLC‐MS) was used for untargeted metabolomic analysis of amniotic fluid samples from women having normal and trisomy 21 fetuses. RESULTS: Many significantly changed metabolites were identified between amniotic fluid samples from Trisomy 21 pregnancies and normal euploid pregnancies, such as generally lower levels of several steroid hormones and their derivatives, higher levels of glutathione catabolites coupled with lower levels of gamma‐glutamyl amino acids, and increased levels of phospholipid catabolites, sugars, and dicarboxylic acids. The identification of a human milk oligosaccharide in amniotic fluid may worth further investigation, since confirmation of this observation may have significant implications for regulation of fetal development. CONCLUSIONS: The metabolisms in amniotic fluid from Trisomy 21 and normal pregnancies are quite different, and some of the significantly changed metabolites may be considered as candidates of early diagnostic biomarkers for Trisomy 21. John Wiley and Sons Inc. 2019-11-10 /pmc/articles/PMC7083445/ /pubmed/31709651 http://dx.doi.org/10.1002/jcla.23089 Text en © 2019 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Liu, Xiaoting Quan, Sheng Fu, Yurong Wang, Weiwei Zhang, Wenling Wang, Xiaofei Zhang, Chenxi Xiang, Daijun Zhang, Liwen Wang, Chengbin Study on amniotic fluid metabolism in the second trimester of Trisomy 21 |
title | Study on amniotic fluid metabolism in the second trimester of Trisomy 21 |
title_full | Study on amniotic fluid metabolism in the second trimester of Trisomy 21 |
title_fullStr | Study on amniotic fluid metabolism in the second trimester of Trisomy 21 |
title_full_unstemmed | Study on amniotic fluid metabolism in the second trimester of Trisomy 21 |
title_short | Study on amniotic fluid metabolism in the second trimester of Trisomy 21 |
title_sort | study on amniotic fluid metabolism in the second trimester of trisomy 21 |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083445/ https://www.ncbi.nlm.nih.gov/pubmed/31709651 http://dx.doi.org/10.1002/jcla.23089 |
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