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The predictive value of microRNA‐21 for sepsis risk and its correlation with disease severity, systemic inflammation, and 28‐day mortality in sepsis patients
BACKGROUND: This study aimed to investigate the value of microRNA (miR)‐21 for predicting sepsis risk and its correlation with inflammation, disease severity as well as 28‐day mortality in sepsis patients. METHODS: Totally, 219 sepsis patients and 219 healthy controls (HCs) were recruited. Plasma sa...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083453/ https://www.ncbi.nlm.nih.gov/pubmed/31778243 http://dx.doi.org/10.1002/jcla.23103 |
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author | Na, Lei Ding, Huajie Xing, Enhong Zhang, Yan Gao, Jun Liu, Bin Yu, Jian Zhao, Yanjun |
author_facet | Na, Lei Ding, Huajie Xing, Enhong Zhang, Yan Gao, Jun Liu, Bin Yu, Jian Zhao, Yanjun |
author_sort | Na, Lei |
collection | PubMed |
description | BACKGROUND: This study aimed to investigate the value of microRNA (miR)‐21 for predicting sepsis risk and its correlation with inflammation, disease severity as well as 28‐day mortality in sepsis patients. METHODS: Totally, 219 sepsis patients and 219 healthy controls (HCs) were recruited. Plasma samples were obtained from sepsis patients within 24 hours after admission and from HCs at the enrollment to detect miR‐21 expressions by real‐time quantitative polymerase chain reaction. Besides, the clinical characteristics of sepsis patients were recorded and the 28‐day mortality of sepsis patients was evaluated. RESULTS: MiR‐21 expression was decreased in sepsis patients compared with HCs, and further receiver operating characteristic (ROC) curve analysis revealed that miR‐21 was of a good value in predicting sepsis risk (area under the curve [AUC]: 0.801, 95% CI: 0.758‐0.844). Besides, miR‐21 expression was negatively associated with acute pathologic and chronic health evaluation II (APACHE II) and sequential organ failure assessment (SOFA) score in sepsis patients. Furthermore, miR‐21 expression was negatively correlated with serum creatinine, C‐reactive protein, tumor necrosis factor‐α, interleukin (IL)‐1β, IL‐6, and IL‐17, while positively correlated with albumin in sepsis patients. However, there was no correlation of miR‐21 expression with white blood cell, smoke, or comorbidities in sepsis patients. Additionally, ROC curve analysis displayed that miR‐21 exhibited a poor predictive value for 28‐day mortality risk in sepsis patients (AUC: 0.588, 95% CI: 0.505‐0.672). CONCLUSION: MiR‐21 might serve as a potential biomarker for the development and progression of sepsis, while not for prognosis prediction in sepsis patients. |
format | Online Article Text |
id | pubmed-7083453 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70834532020-03-24 The predictive value of microRNA‐21 for sepsis risk and its correlation with disease severity, systemic inflammation, and 28‐day mortality in sepsis patients Na, Lei Ding, Huajie Xing, Enhong Zhang, Yan Gao, Jun Liu, Bin Yu, Jian Zhao, Yanjun J Clin Lab Anal Research Articles BACKGROUND: This study aimed to investigate the value of microRNA (miR)‐21 for predicting sepsis risk and its correlation with inflammation, disease severity as well as 28‐day mortality in sepsis patients. METHODS: Totally, 219 sepsis patients and 219 healthy controls (HCs) were recruited. Plasma samples were obtained from sepsis patients within 24 hours after admission and from HCs at the enrollment to detect miR‐21 expressions by real‐time quantitative polymerase chain reaction. Besides, the clinical characteristics of sepsis patients were recorded and the 28‐day mortality of sepsis patients was evaluated. RESULTS: MiR‐21 expression was decreased in sepsis patients compared with HCs, and further receiver operating characteristic (ROC) curve analysis revealed that miR‐21 was of a good value in predicting sepsis risk (area under the curve [AUC]: 0.801, 95% CI: 0.758‐0.844). Besides, miR‐21 expression was negatively associated with acute pathologic and chronic health evaluation II (APACHE II) and sequential organ failure assessment (SOFA) score in sepsis patients. Furthermore, miR‐21 expression was negatively correlated with serum creatinine, C‐reactive protein, tumor necrosis factor‐α, interleukin (IL)‐1β, IL‐6, and IL‐17, while positively correlated with albumin in sepsis patients. However, there was no correlation of miR‐21 expression with white blood cell, smoke, or comorbidities in sepsis patients. Additionally, ROC curve analysis displayed that miR‐21 exhibited a poor predictive value for 28‐day mortality risk in sepsis patients (AUC: 0.588, 95% CI: 0.505‐0.672). CONCLUSION: MiR‐21 might serve as a potential biomarker for the development and progression of sepsis, while not for prognosis prediction in sepsis patients. John Wiley and Sons Inc. 2019-11-28 /pmc/articles/PMC7083453/ /pubmed/31778243 http://dx.doi.org/10.1002/jcla.23103 Text en © 2019 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Articles Na, Lei Ding, Huajie Xing, Enhong Zhang, Yan Gao, Jun Liu, Bin Yu, Jian Zhao, Yanjun The predictive value of microRNA‐21 for sepsis risk and its correlation with disease severity, systemic inflammation, and 28‐day mortality in sepsis patients |
title | The predictive value of microRNA‐21 for sepsis risk and its correlation with disease severity, systemic inflammation, and 28‐day mortality in sepsis patients |
title_full | The predictive value of microRNA‐21 for sepsis risk and its correlation with disease severity, systemic inflammation, and 28‐day mortality in sepsis patients |
title_fullStr | The predictive value of microRNA‐21 for sepsis risk and its correlation with disease severity, systemic inflammation, and 28‐day mortality in sepsis patients |
title_full_unstemmed | The predictive value of microRNA‐21 for sepsis risk and its correlation with disease severity, systemic inflammation, and 28‐day mortality in sepsis patients |
title_short | The predictive value of microRNA‐21 for sepsis risk and its correlation with disease severity, systemic inflammation, and 28‐day mortality in sepsis patients |
title_sort | predictive value of microrna‐21 for sepsis risk and its correlation with disease severity, systemic inflammation, and 28‐day mortality in sepsis patients |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083453/ https://www.ncbi.nlm.nih.gov/pubmed/31778243 http://dx.doi.org/10.1002/jcla.23103 |
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