Quantification of total and unbound cefuroxime in plasma by ultra‐performance liquid chromatography tandem mass spectrometry in a cohort of critically ill patients with hypoalbuminemia and renal failure

BACKGROUND: Pharmacokinetic studies of cefuroxime by ultra‐performance liquid chromatography tandem mass spectrometry (UPLC‐MS/MS) have been limited to measurements of total concentrations. Here, we developed a robust method for quantifying total and unbound cefuroxime concentrations using UPLC‐MS/M...

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Detalles Bibliográficos
Autores principales: van Raaij, Joost J., Mabelis, Noortje J. D., Shudofsky, Kimberly N., Meenks, Sjoerd D., le Noble, Jos L. M. L., Janssen, Paddy K. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083463/
https://www.ncbi.nlm.nih.gov/pubmed/31785116
http://dx.doi.org/10.1002/jcla.23100

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