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Alpha Rhythms Reveal When and Where Item and Associative Memories Are Retrieved

Memories for past experiences can range from vague recognition to full-blown recall of associated details. Electroencephalography has shown that recall signals unfold a few hundred milliseconds after simple recognition, but has only provided limited insights into the underlying brain networks. Funct...

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Autores principales: Martín-Buro, María Carmen, Wimber, Maria, Henson, Richard N., Staresina, Bernhard P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083536/
https://www.ncbi.nlm.nih.gov/pubmed/32034067
http://dx.doi.org/10.1523/JNEUROSCI.1982-19.2020
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author Martín-Buro, María Carmen
Wimber, Maria
Henson, Richard N.
Staresina, Bernhard P.
author_facet Martín-Buro, María Carmen
Wimber, Maria
Henson, Richard N.
Staresina, Bernhard P.
author_sort Martín-Buro, María Carmen
collection PubMed
description Memories for past experiences can range from vague recognition to full-blown recall of associated details. Electroencephalography has shown that recall signals unfold a few hundred milliseconds after simple recognition, but has only provided limited insights into the underlying brain networks. Functional magnetic resonance imaging (fMRI) has revealed a “core recollection network” (CRN) centered on posterior parietal and medial temporal lobe regions, but the temporal dynamics of these regions during retrieval remain largely unknown. Here we used Magnetoencephalography in a memory paradigm assessing correct rejection (CR) of lures, item recognition (IR) and associative recall (AR) in human participants of both sexes. We found that power decreases in the alpha frequency band (10–12 Hz) systematically track different mnemonic outcomes in both time and space: Over left posterior sensors, alpha power decreased in a stepwise fashion from 500 ms onward, first from CR to IR and then from IR to AR. When projecting alpha power into source space, the CRN known from fMRI studies emerged, including posterior parietal cortex (PPC) and hippocampus. While PPC showed a monotonic change across conditions, hippocampal effects were specific to recall. These region-specific effects were corroborated by a separate fMRI dataset. Importantly, alpha power time courses revealed a temporal dissociation between item and associative memory in hippocampus and PPC, with earlier AR effects in hippocampus. Our data thus link engagement of the CRN to the temporal dynamics of episodic memory and highlight the role of alpha rhythms in revealing when and where different types of memories are retrieved. SIGNIFICANCE STATEMENT Our ability to remember ranges from the vague feeling of familiarity to vivid recollection of associated details. Scientific understanding of episodic memory thus far relied upon separate lines of research focusing on either temporal (via electroencephalography) or spatial (via functional magnetic resonance imaging) dimensions. However, both techniques have limitations that have hindered understanding of when and where memories are retrieved. Capitalizing on the enhanced temporal and spatial resolution of magnetoencephalography, we show that changes in alpha power reveal both when and where different types of memory are retrieved. Having access to the temporal and spatial characteristics of successful retrieval provided new insights into the cross-regional dynamics in the hippocampus and parietal cortex.
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spelling pubmed-70835362020-03-23 Alpha Rhythms Reveal When and Where Item and Associative Memories Are Retrieved Martín-Buro, María Carmen Wimber, Maria Henson, Richard N. Staresina, Bernhard P. J Neurosci Research Articles Memories for past experiences can range from vague recognition to full-blown recall of associated details. Electroencephalography has shown that recall signals unfold a few hundred milliseconds after simple recognition, but has only provided limited insights into the underlying brain networks. Functional magnetic resonance imaging (fMRI) has revealed a “core recollection network” (CRN) centered on posterior parietal and medial temporal lobe regions, but the temporal dynamics of these regions during retrieval remain largely unknown. Here we used Magnetoencephalography in a memory paradigm assessing correct rejection (CR) of lures, item recognition (IR) and associative recall (AR) in human participants of both sexes. We found that power decreases in the alpha frequency band (10–12 Hz) systematically track different mnemonic outcomes in both time and space: Over left posterior sensors, alpha power decreased in a stepwise fashion from 500 ms onward, first from CR to IR and then from IR to AR. When projecting alpha power into source space, the CRN known from fMRI studies emerged, including posterior parietal cortex (PPC) and hippocampus. While PPC showed a monotonic change across conditions, hippocampal effects were specific to recall. These region-specific effects were corroborated by a separate fMRI dataset. Importantly, alpha power time courses revealed a temporal dissociation between item and associative memory in hippocampus and PPC, with earlier AR effects in hippocampus. Our data thus link engagement of the CRN to the temporal dynamics of episodic memory and highlight the role of alpha rhythms in revealing when and where different types of memories are retrieved. SIGNIFICANCE STATEMENT Our ability to remember ranges from the vague feeling of familiarity to vivid recollection of associated details. Scientific understanding of episodic memory thus far relied upon separate lines of research focusing on either temporal (via electroencephalography) or spatial (via functional magnetic resonance imaging) dimensions. However, both techniques have limitations that have hindered understanding of when and where memories are retrieved. Capitalizing on the enhanced temporal and spatial resolution of magnetoencephalography, we show that changes in alpha power reveal both when and where different types of memory are retrieved. Having access to the temporal and spatial characteristics of successful retrieval provided new insights into the cross-regional dynamics in the hippocampus and parietal cortex. Society for Neuroscience 2020-03-18 /pmc/articles/PMC7083536/ /pubmed/32034067 http://dx.doi.org/10.1523/JNEUROSCI.1982-19.2020 Text en Copyright © 2020 Martín-Buro et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License Creative Commons Attribution 4.0 International (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Research Articles
Martín-Buro, María Carmen
Wimber, Maria
Henson, Richard N.
Staresina, Bernhard P.
Alpha Rhythms Reveal When and Where Item and Associative Memories Are Retrieved
title Alpha Rhythms Reveal When and Where Item and Associative Memories Are Retrieved
title_full Alpha Rhythms Reveal When and Where Item and Associative Memories Are Retrieved
title_fullStr Alpha Rhythms Reveal When and Where Item and Associative Memories Are Retrieved
title_full_unstemmed Alpha Rhythms Reveal When and Where Item and Associative Memories Are Retrieved
title_short Alpha Rhythms Reveal When and Where Item and Associative Memories Are Retrieved
title_sort alpha rhythms reveal when and where item and associative memories are retrieved
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083536/
https://www.ncbi.nlm.nih.gov/pubmed/32034067
http://dx.doi.org/10.1523/JNEUROSCI.1982-19.2020
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